Liver cancer mortality statistics

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Deaths

Deaths from liver cancer, 2015-2017, UK.

Proportion of all deaths

Percentage liver cancer contributes to total cancer deaths, 2015-2017, UK

Age

Peak mortality rate for liver cancer, 2015-2017, UK

Trend over time

Change in liver cancer mortality rates since the early 1970s, UK

Liver cancer is the 8th most common cause of cancer death in the UK, accounting for 3% of all cancer deaths (2017).[1-3]

In females in the UK, liver cancer is the 11th most common cause of cancer death (3% of all female cancer deaths). In males in the UK it is the 8th most common cause of cancer death (4% of all male cancer deaths).

39% of liver cancer deaths in the UK are in females, and 61% are in males.

Liver cancer mortality rates (European age-standardised (AS) rates) for persons are significantly higher than the UK average in Scotland, and similar to the UK average in all other UK constituent countries.

Liver Cancer (C22), Number of Deaths, Crude and European Age-Standardised (AS) Mortality Rates per 100,000 Population, UK, 2017

  England Scotland Wales Northern Ireland UK
Female Deaths 1,810 256 119 49 2,234
Crude Rate 6.4 9.2 7.5 5.2 6.7
AS Rate 6.4 8.8 6.6 5.6 6.6
AS Rate - 95% LCL 6.1 7.7 5.4 4.1 6.3
AS Rate - 95% UCL 6.7 9.9 7.8 7.2 6.8
Male Deaths 2,817 375 201 84 3,477
Crude Rate 10.3 14.2 13.1 9.1 10.7
AS Rate 12.0 16.4 13.5 12.1 12.5
AS Rate - 95% LCL 11.6 14.8 11.6 9.5 12.1
AS Rate - 95% UCL 12.5 18.1 15.3 14.7 12.9
Persons Deaths 4,627 631 320 133 5,711
Crude Rate 8.3 11.6 10.2 7.1 8.6
AS Rate 9.0 12.1 9.8 8.5 9.3
AS Rate - 95% LCL 8.7 11.2 8.7 7.0 9.0
AS Rate - 95% UCL 9.2 13.0 10.9 9.9 9.5

95% LCL and 95% UCL are the 95% lower and upper confidence limits  around the AS Rate 
 

For liver cancer mortality differences between countries largely reflect differences in incidence.

References

  1. Data were provided by the Office for National Statistics on request, November 2018. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths.
  2. Data were provided by ISD Scotland on request, October 2018. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Northern Ireland Cancer Registry on request, March 2019. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2017, ICD-10 C22.

Last reviewed:

Liver cancer mortality is strongly related to age, with the highest mortality rates being in older people. In the UK in 2015-2017, on average each year half (50%) of deaths were in people aged 75 and over.[1-3] This largely reflects higher incidence and lower survival for liver cancer in older people.

Age-specific mortality rates rise steadily from around age 45-49 and more steeply from around age 60-64. The highest rates are in the 85 to 89 age group for females and males. Mortality rates are significantly lower in females than males in a number of (mainly older) age groups. The gap is widest at age 20 to 24,when the age-specific mortality rate is 8.6 times lower in females than in males.

Liver Cancer (C22), Average Number of Deaths per Year and Age-Specific Mortality Rates per 100,000 Population, UK, 2015-2017

95% LCL and 95% UCL are the 95% lower and upper confidence limits around the AS Rate

References

  1. Data were provided by the Office for National Statistics on request, November 2018. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths.
  2. Data were provided by ISD Scotland on request, October 2018. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Northern Ireland Cancer Registry on request, March 2019. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2015-2017, ICD-10 C22.

Last reviewed:

Liver cancer European age-standardised (AS) mortality rates for females and males combined increased by 216% in the UK between 1971-1973 and 2015-2017.[1-3] The increase was of a similar size in females and males.

For females, liver cancer AS mortality rates in the UK increased by 205% between 1971-1973 and 2015-2017. For males, liver cancer AS mortality rates in the UK increased by 209% between 1971-1973 and 2015-2017.

Over the last decade in the UK (between 2005-2007 and 2015-2017), liver cancer AS mortality rates for females and males combined increased by 51%. In females AS mortality rates increased by 55%, and in males rates increased by 47%.

Liver Cancer (C22), European Age-Standardised Mortality Rates per 100,000 Population, UK, 1971-2017

For most cancer types, mortality trends largely reflect incidence and survival trends. For example, rising mortality may reflect rising incidence and stable survival, while falling mortality may reflect rising incidence and rising survival.

Liver cancer mortality rates have increased overall in all broad adult age groups in females and males combined in the UK since the early 1970s.[1-3] Rates in 25-49s have increased by 48%, in 50-59s have increased by 113%, in 60-69s have increased by 195%, in 70-79s have increased by 235%, and in 80+s have increased by 317%.

Liver Cancer (C22), European Age-Standardised Mortality Rates per 100,000 Population, By Age, UK, 1971-2017

References

  1. Data were provided by the Office for National Statistics on request, November 2018. Similar data can be found here: http://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/deaths.
  2. Data were provided by ISD Scotland on request, October 2018. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Northern Ireland Cancer Registry on request, March 2019. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1971-2017, C22.

Last reviewed:

Liver cancer mortality rates are projected to rise by 58% in the UK between 2014 and 2035, to 16 deaths per 100,000 people by 2035.[1] This includes a larger increase for males than for females.

For males, liver cancer European age-standardised (AS) Open a glossary item mortality rates in the UK are projected to rise by 57% between 2014 and 2035, to 22 deaths per 100,000 by 2035.[1] For females, rates are projected to rise by 53% between 2014 and 2035, to 11 deaths per 100,000 by 2035.[1]

Liver cancer (C22), Observed and Projected Age-Standardised Mortality Rates, by Sex, UK, 1979-2035

 

It is projected that 12,179 deaths from liver cancer (7,449 in males, 4,730 in females) will occur in the UK in 2035.

References

  1. Smittenaar CR, Petersen KA, Stewart K, Moitt N. Cancer Incidence and Mortality Projections in the UK Until 2035. Brit J Cancer 2016.

About this data

Data is for: UK, 1979-2014 (observed), 2015-2035 (projected), ICD-10 C22

Projections are based on observed incidence and mortality rates and therefore implicitly include changes in cancer risk factors, diagnosis and treatment. It is not possible to assess the statistical significance of changes between 2014 (observed) and 2035 (projected) figures. Confidence intervals are not calculated for the projected figures. Projections are by their nature uncertain because unexpected events in future could change the trend. It is not sensible to calculate a boundary of uncertainty around these already uncertain point estimates. Changes are described as 'increase' or 'decrease' if there is any difference between the point estimates.

More on projections methodology

Last reviewed:

There is evidence for a strong association between liver cancer mortality and deprivation for both males and females in England.[1] England-wide data for 2007-2011 show European age-standardised Open a glossary item mortality rates are 100% higher for males living in the most deprived areas compared with the least deprived, and 72% higher for females.[1]

Liver Cancer (C22), European Age-Standardised Mortality Rates by Deprivation Quintile, England, 2007-2011

The estimated deprivation gradient in liver cancer mortality between people living in the most and least deprived areas in England has not changed in the period 2002-2011.[1] It has been estimated that there would have been around 600 fewer cancer deaths each year in England during 2007-2011 if all people experienced the same mortality rates as the least deprived.[1]

Reference

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014.

About this data

Data is for: UK, 2007-2011, ICD-10 C22

Deprivation gradient statistics were calculated using mortality data for 2007-2011. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

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Acknowledgements

We are grateful to the many organisations across the UK which collect, analyse, and share the data which we use, and to the patients and public who consent for their data to be used. Find out more about the sources which are essential for our statistics.