Recently funded awards

November 2024

Biomarker Project Awards

Dr Jun Wang, Queen Mary University of London

Evaluation and refinement of a multigene prognostic signature and digital histology AI features for the prediction of metastasis in cutaneous squamous cell carcinoma

Dr Santiago Zelenay and Professor Caroline Dive, CRUK Manchester Institute

Pro-tumourigenic inflammation as a predictor of relapse post-surgery in early-stage non-small cell lung cancer

Prospective Sample Collection Awards

Professor Simon Gollins, Professor David Sebag-Montefiore and Dr Mark Saunders, University of Leeds

Augmenting Radiotherapy in Rectal Cancer to Minimise Invasive Surgery (ARTEMIS) Sample Collection

Dr Claire O’Leary, University of Manchester

Sample collection in early preoperative intervention studies in Glioblastoma: POBIG and PORTRAIT 

Clinical Trial Awards

Dr Jenny Gains and Professor Darren Hargrave, University College London

CONNECT2007: Phase I/II Study of Lutathera in Patients With Recurrent and/or Progressive High-Grade Central Nervous System Tumors and Meningiomas That Demonstrate Uptake on DOTATATE PET 

Professor Robert Huddart, Dr Alison Reid and Dr Fay Cafferty, Institute of Cancer Research

A phase II/III trial evaluating use of circulating serum miRNA as part of active surveillance for patients with stage I seminoma and dysgerminoma (OTIS-S)

Experimental Medicine Awards

Professor Anthony Moorman, Newcastle University

BIOINFORM: Biologically informed treatment decisions in acute leukaemia

Clinical Trial Award Endorsement

Professor Christopher Fox, University of Nottingham

RAdICAL - Risk-Adapted Immunochemotherapy to Cure Aggressive Lymphoma

Dr Andrew Clamp, University College London

SALVOVAR trial: A pragmatic randomized phase III trial to assess the utility of adjusting chemotherapy dose & dosing schedule with the SALVage weekly dose-dense regimen in patients with poor prognostic OVARian cancers based on the tumor primary chemosensitivity and incomplete debulking surgery

 

May 2024

Biomarker Project Awards

Dr Alexandra Clipson and Dr Alicia-Marie Conway (University of Manchester)

Determining tissue-of-origin from circulating free DNA profiling for diagnosis of Cancers of Unknown Primary

Dr Nicholas McGranahan and Dr James Black (University College London)

GENESIS: Genomic Evaluation of a Novel Ensemble Signature for Immunotherapy Stratification

Prospective Sample Collection Awards

Dr Ashwin Sachdeva, Professor Noel Clarke and Professor Gert Attard (University of Manchester and University College London)

Collection of diagnostic tissue blocks from the STAMPEDE metformin trial in advanced prostate cancer

Clinical Trial Awards

Professor Adele Fielding (University College London)

UKALL15

Professor Gordon Cook and Dr Charlotte Pawlyn (University of Leeds and Institute of Cancer Research)

UK-MRA Myeloma XVIII iFIT: Immunotherapy approaches adapted for Fitness In newly diagnosed Transplant ineligible patients with Myeloma

Experimental Medicine Awards

Professor Gary Middleton and Professor Caroline Dive (University of Birmingham and University of Manchester)

A translational programme for DETERMINE (Determining Extended Therapeutic indications for Existing drugs in Rare Molecularly-defined Indications using a National Evaluation platform trial)

 

November 2023

Biomarker Project Awards

Professor Ming-Qing Du (University of Cambridge)

Precision Prognostic Utility of MYC translocation in Aggressive B-cell lymphomas

Clinical Trial Awards

Dr Frederik van Delft (Newcastle University)

Hem-iSmart international early phase clinical trial platform

Professor Steven Knapper and Dr Richard Dillon (Cardiff University and Kings College London)

Optimise-FLT3 Study: Optimising therapy for patients with FLT3-mutated Acute Myeloid Leukaemia

Dr Fiona McDonald and Prof Judith Bliss (Institute of Cancer Research)

HALT - Targeted therapy with or without dose intensified radiotherapy for oligo-progressive disease in oncogene-addicted lung tumours (Costed Extension)

 

July 2023

Prospective Sample Collection Awards

Dr Anna Wilkins and Professor Emma Hall (Institute of Cancer Research)

3P sample collection application

Dr Ann Henry, Dr Finbar Slevin, Dr Alexandra Clipson (University of Leeds)

POINTER-PC SC: Evaluating molecular markers of radiotherapy efficacy and toxicity for pelvic nodal recurrence in prostate cancer

Dr Christopher Williams and Professor Andrew Beggs (University of Leeds)

ctDNA collection within the ARIEL trial: A biomarker enrichment trial of anti-EGFR agents in right primary tumour location, RAS wild-type, advanced colorectal cancer (aCRC)

Clinical Trial Awards

Professor Gordon Jayson and Professor Richard Adams (University of Manchester)

VALTIVE1b: Validation of Tie2 for VEGF inhibitors in Patients With Ovarian Cancer Treated With Olaparib and Bevacizumab Maintenance Therapy: Optimising the Design (Costed Extension)

Professor Michael Schmid, Professor Paula Ghaneh, Dr Ainhoa Mielgo, Professor Daniel Palmer (University of Liverpool)

Investigating the translational potential of inhibiting AXL in combination with adjuvant chemotherapy in the treatment of pancreatic cancer. (Pre-Clinical Package)

Experimental Medicine Awards

Professor Louis Chesler, Professor Darren Hargrave and Dr Isidro Cortés-Ciriano (Institute of Cancer Research)

Stratified Medicine Paediatrics 2 (StratMedPaediatrics2)
 

March 2023

Clinical Trial Awards

Professor Darren Hargrave, University of Birmingham

CRUK/23/002: BIOMEDE 2.0: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication

Dr Reuben Benjamin, Professor Christina Yap, Dr Charlotte Graham, Dr John Maher, King's College Hospital NHS Foundation Trust

CRUK/23/003: pCAR19: Phase 1, open label, dose escalation study evaluating the safety and efficacy of next generation anti-CD19 parallel chimeric antigen receptor T cells (pCAR19) in patients with relapsed/refractory B-cell lymphomas

Prospective Sample Collection Awards

Dr Elizabeth Phillips, Dr Kim Linton, University of Manchester

RADAR sample collection: a randomised phase III study with a PET response-adapted design comparing ABVD +/- ISRT with A2VD +/- ISRT in patients with previously untreated stage IA/IIA Hodgkin lymphoma

November 2024

​​Programme Awards

Professor Adam Mead, University of Oxford

Gene-Environment Initiated Disease Progression in Myeloproliferative Neoplasm

Professor Rahul Roychoudhuri, University of Cambridge

Targeting the stem-like maintenance programme of Treg cells to reverse immune suppression and immunotherapy resistance in cancer

Professor Simon Robinson, Institute of Cancer Research

Advancing MRI Biomarkers of the Tumour Microenvironment for Patient Benefit

Professor Philip Jones, Wellcome Sanger Institute

Outcompeting oncogenesis: oesophageal cancer prevention by manipulating mutant fitness.

Professor Keith Caldecott, University of Sussex

Nascent DNA Strand Maturation in Human Cells and its Targeting by Inhibitors of Poly(ADP-Ribose) Metabolism

Professor Bart Vanhaesebroeck, University College London

PI3K in cancer biology and therapy

Professor Eric Miska, University of Cambridge

The role of RNA structure and modification in cancer

Programme Foundation Awards

Dr Robert Köchl and Professor Marco Fritzsche, King’s College London and University of Oxford

T Cells Under Pressure

Dr Anestis Tsakiridis, University of Sheffield

Elucidating the role of chromosomal copy number variants in neuroblastoma

Dr Faraz Mardakheh, University of Oxford

Understanding and exploiting ribosome biogenesis dysregulation in cancer

Dr Lisa Russell, Newcastle University

Discovering and targeting the wider super-enhancer network of acute lymphoblastic leukaemia

Multidisciplinary Project Awards

Professor Mark Lythgoe and Dr Martin Pule, University College London

Glymphatic brain clearance: A novel therapeutic target in Glioblastoma.

Cancer Immunology Project Awards

Professor Dimitris Lagos, University of York

Transcriptome instability as a determinant of renal cancer immunotherapy outcomes

 

June 2024

​​Programme Awards

Professor Jessica Downs, Institute of Cancer Research

Investigating the contribution of chromatin dynamics to DNA damage responses and genome stability

Professor Zoltan Takats, Dr Burak Temelkuran, Professor Sadaf Ghaem- Maghami, Imperial College London & Professor Josephine Bunch, National Physical Laboratory

Cancer surgery at systems medicine level: simultaneous molecular mapping and resecting of solid tumours using spectroscopically guided semi-autonomous surgical robots

Professor Sergio Quezada, University College London

Deciphering Immune Reactivities and Regulatory Contexture in Brain Tumours to Advance the Development of Novel Immunotherapies.

Professor Alan Warren, University of Cambridge

Targeting the ribosome as a pan-cancer therapy

Programme Foundation Awards

Dr Paul Elliott, University of Oxford

Controlling survival of aneuploid glioma cancer cells through E3 ubiquitin ligases: role of BIRC6 and UBR4

Dr Sarah McClelland, Queen Mary University London

Defining the origins and vulnerabilities of cancer chromosomal instability

Multidisciplinary Project Awards

Dr Fernando Perez-Cota, Dr Alan McIntyre & Dr Matt Clark, University of Nottingham

The sound of Cancer: towards elasticity biomarkers

Dr Emma Harris & Professor Kairbaan Hodivala-Dilke, Institute of Cancer Research and Queen Mary University London

Tools for the early signposting of treatment resistance and metastasis in pancreatic cancer.

Cancer Immunology Project Awards

Professor Kevin Marchbank & Professor Helen Reeves, Newcastle University

Hyperactive complement driving inflam-ageing: a shortcut to cancer?

Professor Irina Udalova, University of Oxford & Professor Iain McNeish, Imperial College London

Decoding spatiotemporal heterogeneity of neutrophil subsets during ovarian cancer

 

November 2023

​​Programme Awards

Professor Linda Wooldridge, University of Bristol

Identification of antigens targeted by T-cells mediating Graft-versus-Leukaemia and Graft-versus-Host Disease following Stem Cell Transplantation

Professor Pascal Meier, Institute of Cancer Research

Harnessing Cell Death Mechanisms in Cancer

Professor Peter McHugh & Professor Christopher Schofield, University of Oxford

Targeting nucleases for the treatment of cancer

Professor Jussi Taipale, University of Cambridge

Identification and targeting of common regulatory mechanisms underlying major forms of human cancer

Programme Foundation Awards

Dr Luca Magnani, Institute of Cancer Research

Disarming Dormancy: preventing evolution by targeting oestrogen receptor dormant cells in healthy and cancer tissues (DiDo)

Dr Nicholas McGranahan, University College London

Dissecting Evolutionary phenotypes in Cancer by Investigating Plasticity and Heritability in Evolution and Resistance (DECIPHER)

Dr Audrey Gerard, University of Oxford

Studying the coevolving cancer and immune landscapes – unravelling targetable pathways of immune adaptation

Dr Helen Rowe, Queen Mary University of London

Crosstalk between chromatin remodelling and immune evasion in non-small cell lung cancer (NSCLC)

Multidisciplinary Project Awards

Professor Campbell Roxburgh, Professor Joanne Edwards, University of Glasgow & Professor Emiliano Spezi, Cardiff University

Derivation of novel non-invasive radiomic and AI-based classifiers to determine molecular behaviour of rectal cancer and its treatment response to radiotherapy

Professor Oscar Ces & Professor Charlotte Bevan, Imperial College London

Cancer Research UK & Prostate Cancer UK Innovation Award: Microenvironment-Remodelling Synthetic Cells for Cancer Drug Delivery (DRCMDP-May23/100012 and RIA22-ST2-010)

Cancer Immunology Project Awards

Dr Ricardo Fernandes, University of Oxford

Identification of structural and functional correlates of robust antitumour T cell responses

 

June 2023

​​Programme Awards

Professor Katrin Ottersbach, University of Edinburgh

The role of the microenvironment in the initiation and maintenance of infant leukaemia

Dr Ingo Ringshausen, University of Cambridge

Oncogene & tumour suppressor-mediated remodelling of the tumour microenvironment in B cell lymphoproliferative diseases

Professor Simona Parrinello, University College London
Glioblastoma Initiation and Re-initiation

Professor Christian Siebold, University of Oxford

Molecular Mechanisms of Morphogen Signalling in the Tumour Microenvironment

Professor Mark Cragg & Professor Stephen Beers, University of Southampton
Targeting myeloid cells for improved antibody immunotherapy

Professor Ronald Hay, University of Dundee

New players in the targeted degradation of the PML-RARA oncogene by arsenic

Programme Foundation Awards

Dr Christopher Tape, University College London

Treatment Analysis via Individualised Organoid Responses (TAILOR)

Multidisciplinary Project Awards

Dr Ran Yan, Dr John Maher, Dr James Arnold & Professor Erik Arstad, Kings College London

Development of Novel 18F-labelled Molecular Probes for Long-Term CAR T-cell Tracking with Positron Emission Tomography (CART_PET)

Cancer Immunology Project Awards

Professor Jessica Strid, Imperial College London

Contribution of bioactive lipid mediators to inflammation and epithelial cancer development

November 2024

Project Awards

Professor John Doorbar & Dr Nagayasu Egawa, University of Cambridge 
Spatial Mapping of Cervical Precancers: Combined use of Molecular Markers and Cytology for Disease Monitoring and to Understand the Natural History/Progression Risk

Dr Ceri Bygrave & Professor Karthik Ramasamy, University of Oxford
Early detection of relapse in multiple myeloma patients with high risk genetics using quantitative immunoprecipitation-mass spectrometry (QIP-MS) in blood: an enhanced surveillance platform for the Myeloma XV, RADAR trial

Professor Elizabeth Soilleux, University of Cambridge
A rapid antibody-based assay for conclusive early diagnosis of T cell lymphoma

Professor Georgios Lyratzopoulos & Dr Matthew Barclay, University College London
Improving survival by understanding avoidable emergency diagnosis and related inequalities

Professor Sharon Hanley, University of Aberdeen
Improving Cervical Cancer Outcomes in Disadvantaged Populations: Using HPV Self-Sampling to Increase AccessibilitY, Equity, and Participation in Scotland’s National Cervical SCREENing Programme- AYE-SCREEN

Primer Awards

Professor Aled Clayton & Dr Xin Yang, Cardiff University
Acoustic centrifugation to enhance Extracellular vesicle Based Prostate Cancer Diagnosis

Professor Sylvain Ladame, Imperial College London
pH Sensing of Interstitial Skin Fluid with Non-Invasive Hydrogel Patches Can Improve Sensitivity of Skin Cancer Diagnosis in Primary Care

Dr Parinaz Mehdipour, University of Oxford
Identification of circular RNA biomarkers for early detection of normal colon cell transformation into precancerous and colorectal cancer states

Professor Chris Cardwell, Queen's University Belfast
Systematically assessing prescription medication use before cancer diagnosis to identify opportunities for early cancer detection

Dr Greta Skrupskelyte, University of Cambridge
Early Detection of Oesophageal Cancer: Focusing on 10-cell Tumour Analysis

Professor Christian von Wagner, University College London
Developing a community pharmacy service to facilitate early diagnosis of bowel cancer: A rapid ethnographic study

Dr Samantha Salvage, University of Cambridge
Development of a human fragment antibody targeting an early oncogenic biomarker in breast cancer; a tool for detection and diagnosis

 

May 2024

Programme Awards

Professor Nitzan Rosenfeld, Queen Mary University of London & Professor Mark Tischkowitz, University of Cambridge 
Earlier diagnosis in women at high risk of breast and ovarian cancer

Project Awards

Professor Petra Hamerlik, University of Manchester
INFORM - non-invasive early detection of brain cancer using tear fluid proteome profiling

Dr Laura Woods & Dr Christina Dobson, Newcastle University
What does the introduction of Lung Health Checks (LHCs) in England mean for lung cancer inequalities? A mixed methods investigation.

Primer Awards

Dr Sarah Gosling, University of Keele
Early Detection of Ovarian Cancer: Interrogating The Tissue Microenvironment for Novel Biomarkers

Dr Faezeh Arab Hassani, University of Bristol
TACIMApatch: Tactile imaging patch for early detection of breast tumours

Dr Maria Paraskevaidi, Imperial College London
The use of high-throughput blood-based metabolomics for ovarian cancer early detection and diagnosis

Professor John Field, University of Liverpool
Multiomic Lung Cancer Early Detection

Dr Sarah Fry, Cardiff University
Acceptability and accessibility of using peer-led WhatsApp groups for sharing prostate cancer risk information between black men: a pilot study.

Dr Olena Mandrik, University of Sheffield
The use of high-throughput blood-based metabolomics for ovarian cancer early detection and diagnosis

Professor Anita Grigoriadis, King's College London & Professor Laszlo Radvanyi, Ontario Institute for Cancer Research
Transposable Element Activation in Pre-invasive and Early Invasive Breast Cancer Development in High-Risk Women: Developing a Spatial Proteogenomic and Liquid Biopsy Platform for Molecular Characterization and Early Detection

Dr Daniel Middleton, Queen's University Belfast & Dr Ismail Hosen, University of Dhaka
Liquid biopsy biomarkers for the early detection of bladder cancer in an arsenic exposed population (UroScan)

Dr Steven Ersser, Bournemouth University
Developing evidence and theory-informed digital videos employing a user-centred participatory approach, to support the early detection of skin cancer (EDSC) via self-examination of the skin (SSE), focused on at-risk (older men) and under-served populations (‘people of colour’)

Dr Christina Renzi, University College London
Cancer diagnosis in people with disability: a multi-methods international project on diagnostic pathways and cancer outcomes

 

November 2023

Programme Awards

Professor David Weller, University of Edinburgh & Professor Peter Sasieni, Queen Mary University of London 
Risk-based screening in UK colorectal cancer screening programmes

Project Awards

Dr Massimiliano di Pietro, University of Cambridge & Dr Florian Markowetz, CRUK Cambridge Institute
Artificial intelligence based early detection of signet ring cell carcinoma in hereditary diffuse gastric cancer patients

Dr Ruchi Gupta, University of Birmingham
Smart Hydrogels and Devices for Early Detection of Cancer

Dr James Flanagan, Imperial College London
The Cancer Loyalty Card Study (CLOCS)

Dr Sarah Bailey, University of Exeter
Clinical utility of neutrophil-to-lymphocyte ratio in identifying patients at risk of cancer diagnosis in primary care: a cohort study using routine electronic health records

Professor Daryl O'Connor & Professor Mark Conner, University of Leeds
Increasing FIT bowel cancer screening uptake: Testing the effectiveness of two promising behaviour change interventions and their combination

Dr Rachel Evans & Dr Gilbert Fruhwirth, King's College London
ROR1 Detection As An Early Indicator Of Lung Cancer

Primer Awards

Dr Harriet Quinn-Scoggins, Cardiff University
Preparing healthcare providers and the public for Multi Cancer Early Detection (MCED) blood tests: towards equitable implementation through co-creation

Dr Vasiliki Symeonidou, University of Cambridge
Improving early detection of individuals at high-risk of developing AML and related cancers

Dr Jihong Zhu, University of York & Dr Roisin Bradley, York and Scarborough Teaching Hospital NHS Foundation Trust
Robotic Positioning Assistance in Breast Screening

Dr Stephanie Archer, University of Cambridge
Integrating multifactorial risk assessment within secondary care breast services: co-designing a new pathway

Dr Kirsten Christensen-Jeffries, King's College London
Advanced Ultrasound Imaging for Early Cancer Detection and Diagnosis

Dr Takanori Kitamura, University of Edinburgh
Identification of macrophage-associated biomarkers to predict the progression of ductal carcinoma in situ (DCIS) into invasive breast cancer

Professor Martin Widschwendter, University College London
Establishing optimal and acceptable vaginal self-sampling for epigenetic-based endometrial cancer surveillance in women with Lynch Syndrome

Dr Jamie Weaver & Dr Susanne Flach, LMU Klinikum Munich
Understanding the timings of mutations and microenvironmental changes in head and neck squamous cell carcinoma and associated field cancerization to develop better biomarkers for high-risk patient surveillance and early detection

Dr Hector Huerga Encabo & Professor Dominique Bonnet, The Francis Crick Institute
Detection of early steps of blood cancer

 

May 2023

Project Awards

Professor Peter Murchie, University of Aberdeen
Achieving Self-directed Integrated Cancer Aftercare (ASICA) in melanoma: Optimising the intervention using pilot evidence, assisted intelligence and behavioural science

Professor Shankar Balasubramanian & Professor Rebecca Fitzgerald, University of Cambridge
Evaluation of G-quadruplex profiling for the early detection of oesophageal adenocarcinoma

Dr Ana Rio-Machin & Dr Kevin Rouault-Pierre, Queen Mary University of London 
Deciphering the role of germline variants in the RNA-helicases to improve the early detection and management of familial MDS/AML patients

Dr Professor Richard Shaw & Professor Peter Weightman, University of Liverpool
Clinical and technical validation of infrared absorbance spectra to predict malignant transformation in oral potentially malignant disorders (OPMDs)

Dr Daniel Royston & Professor Jens Rittscher, University of Oxford
Integrating AI-based early detection and assessment of myeloproliferative neoplasms (MPN) into routine clinical pathways

Dr Lizhe Zhuang & Professor Rebecca Fitzgerald, University of Cambridge
Cross-platform study of clonal heterogeneity and microenvironmental niches in initiation and progression of Barrett’s oesophagus and oesophageal adenocarcinoma

Primer Awards

Dr Abish Stephen, Professor Keith Hunter & Dr Geraint Morgan, Queen Mary University of London
Volatile metabolomics for early detection of aerodigestive cancers

Dr Xin Yang, University of Cambridge
Improving endometrial cancer risk prediction for prevention and early detection

Professor David Klenerman & Professor Richard Mair, University of Cambridge
Sensitive detection of P53 aggregates in biofluids  for  the early detection of cancer

Dr Luca Panariello & Dr Adam Creamer, Imperial College London
MagnetoCrisprZyme sensor for quantification of circulating microRNA in primary care settings

Dr Marta Canel, University of Edinburgh
Validating new models to investigate the impact of mutational heterogeneity in the early detection of pancreatic cancer

Professor Neil Hunt, University of York
Ultrafast 2D-IR analysis of liquid biopsies for cancer detection

Dr Marek Palace, Dr Christian von Wagner & Dr Carlos Santos Barea , Liverpool John Moores University
Developing multimodal data-driven art-inspired bowel cancer-screening promotion messages

Dr Ljiljana Fruk, University of Cambridge
Senescence-detecting, urine-based nanobiosensor for early detection of lung cancer

Professor Trevor Graham & Dr Callum Gabbutt, Institute of Cancer Research
Sensitive and specific pan-cancer early detection using fluctuating methylation clocks

November 2024

Programme Awards

Professor Ruth Langley, University College London, & Professor Sir John Burn, Newcastle University
Suppressing Platelet Activation to Reduce Cancer - A New Approach to Cancer Prevention

Professor Bernard Rachet & Professor Ellen Nolte, London School of Hygiene and Tropical Medicine
Inequalities in cancer care and outcomes

Project Awards

Professor Georgios Lyratzopoulos & Dr Matthew Barclay, University College London
Improving lung cancer survival by reducing inequalities to optimal treatment

Biology to Prevention Awards

Dr Karin Hellner, University of Oxford
Development and immunogenicity profiling of HPVax - A therapeutic, broad-coverage mRNA vaccine targeting all oncogenic human papillomaviruses

Professor Rebecca Fitzgerald & Dr John Lizhe Zhuang, University of Cambridge
A biology informed approach to prevent gastric cancer in high-risk individuals

Dr Andrew Gilmore, Dr Sacha Howell, Professor Susan Astley & Dr Sankari Nagarajan, University of Manchester
Developing targeted strategies for precision breast cancer prevention

 

May 2024

Project Awards

Professor Eve Roman & Dr Eleanor Kane, University of York
United Kingdom Childhood Cancer Study (UKCCS): a national population-based study examining the health of cancer survivors

Dr Emma Vincent, University of Bristol & Professor Javier Gonzalez, University of Bath
Does the biological response to ketogenesis influence colorectal cancer risk? – Exploring causality and mechanism.

Dr Helena Carreira, London School of Hygiene and Tropical Medicine
Associations between androgen deprivation therapies and adverse cardiovascular outcomes in men with prostate cancer: a population-based cohort study in England

Biology to Prevention Awards

Dr Luke Boulter, University of Edinburgh
Identifying and eradicating tumour-initiating cells in high-risk cholangiocarcinoma patients

Professor Ahmed Ahmed, University of Oxford
Developing a vaccine for ovarian cancer prevention

Dr Cassie Clarke, Cancer Research UK Scotland Institute
Exploiting pyrimidine metabolism as a cancer prevention and intervention strategy

Dr David Church & Professor Simon Leedham, University of Oxford
LynchVax – a precision prevention vaccination strategy for Lynch Syndrome (LS)

Professor Malcolm Dunlop, University of Edinburgh
Establishing the rationale to develop small molecule drugs to prevent polyps and cancer in Familial Adenomatous Polyposis

Professor Lesley Stark, University of Edinburgh
Use of spatial proteomics to dissect an emerging inflammatory pathway for targeted cancer prevention

 

November 2023

Programme Awards

Professor Christopher Bunce & Professor Mark Drayson, University of Birmingham
Prevention not cure: An interdisciplinary approach to preventing Myeloma

Project Awards

Professor Mark Hamer, University College London
The twenty-four hour physical behaviour spectrum and risk of cancer: The Prospective Physical Activity, Sitting and Sleep consortium (ProPASS)

Professor Catherine Harwood & Dr Rubeta Matin, Cardiff University
SPOT-IT: cutaneous SCC Prevention using tOpical Therapy in Immunosuppressed patienTs

Dr Laura Woods & Professor Linda Sharp, Newcastle University
Investigating deprivation-specific and ethnic inequalities in adherence to endocrine therapy in women with ER+ve breast cancer: can these explain disparities in survival?

Professor Rosalind Eeles, Institute of Cancer Research
IMPACT: Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in men at higher genetic risk and non-carriers – Long term follow up of the Mis-match Repair Gene Cohort

Biology to Prevention Awards

Dr James Reading & Professor Sam Janes, University College London
Targeting early T cell regulation to intercept lung squamous carcinogenesis

Dr Seth Coffelt & Dr Joanne Edwards, University of Glasgow
Investigating immunological prevention strategies for precursor lesions of colon cancer

Professor Tim Elliott, Dr Kevin Litchfield & Professor Sarah Blagden, University of Oxford
LungVax: Preventing lung cancer via targeting hotspot neoantigens with the ChAdOx vaccine platform

Dr Stephanie May, University of Glasgow
Targeting oncogene induced anti-apoptotic pathways for precision prevention in liver cancer

Dr Sanne van Neervan & Professor Benjamin Simons, University of Cambridge
The role of mutant cell competition and cooperation during field cancerization and intestinal adenoma development

Dr Emma Allott, Queen's University Belfast
Repurposing statins for precision prevention of PTEN-null prostate cancer

Dr Yi Feng, University of Edinburgh
Tracing somatic cell acquired oncogenic mutations from inception to investigate tissue environmental contribution to preneoplastic development

Dr Matthew Rose-Zerilli, University of Southampton
Harnessing the activities of gastro-intestinal innate immune cells for the prevention of oesophageal adenocarcinoma

Dr Matthew Ford & Professor James Brenton, CRUK Cambridge Institute
Exploring premalignant lesions of high-grade serous ovarian cancer and response to next generation PARP-inhibitors

 

May 2023

Project Awards

Dr James Yarmolinsky, University of Bristol
Obesity and pancreatic cancer risk: leveraging genetic, observational, and molecular approaches to provide novel insights into causal intermediates to inform cancer prevention

Professor Richard Martin, Professor Jenny Donovan, Professor Freddy Hamdy & Professor David Neal, University of Bristol
Answering key questions needed to inform prostate cancer screening policy: long-term follow-up of the ProtecT (15-year) and CAP (18-year) randomised controlled trials.

Professor Doug Easton, University of Cambridge
Characterisation of novel breast cancer susceptibility genes through large-scale targeted sequencing

Biology to Prevention Awards

Professor Walid Khaled & Dr Sara Pensa, University of Cambridge
Targeting BRCA driven premalignant cellular changes in the breast

Professor Kwee Yong, University College London
Understanding and restoring NK cell (dys)function in smouldering myeloma to optimise intervention strategies to prevent development of multiple myeloma

November 2024

Senior Cancer Research Fellowship

Dr David Church, University of Oxford
Mechanisms, consequences and clinical translation of MHC-I and MHC-II dysregulation in colorectal and endometrial (pre)cancer

Advanced Clinician Scientist Fellowship

Dr Alastair Lamb, Queen Mary University of London
Spatial Prostate Assessment and the Circulating Environment - discovering the lethal clone (SPACE-X)

Career Development Fellowship

Dr Robb Hollis, University of Edinburgh
Identifying strategies for preventing/reversing chemoresistance in ovarian cancer

Dr Kerrie Marie, University of Manchester
Deciphering the dynamics of melanoma plasticity

Career Establishment Award

Dr Robert Kerrison, University of Surrey
Identifying, understanding and addressing inequalities in cancer treatment

Clinician Scientist Fellowship

Dr Anna Wilkins, Institute of Cancer Research
Interrogating and targeting mechanisms by which cancer-associated fibroblasts limit radiotherapy responses in bladder cancer

Pre-doctoral Research Bursary

Dr Vinson Wai-Shun Chan, University of Leeds
Proposal for pre-treatment CT/MRI derived radiomics and machine learning (ML) models for predicting treatment and immune-response in patients undergoing image-guided ablation and histotripsy for small renal masses and liver tumours. A proof-of-concept study

Dr Tirion Hughes, University of Oxford
Developing new cell models for brain tumours which use the Alternative Lengthening of Telomeres pathway

Dr Sarah Rae, Newcastle University
Socio-demographic inequalities of access to novel genomic testing and therapeutics in solid tumours in the UK

Dr Joanna Kucharczak, University of Cambridge
Exploring the potential of polymerase theta inhibition as a strategy for the radiosensitisation of oesophageal adenocarcinoma

Postdoctoral Research Bursary

Dr Rachel Pounds, University of Birmingham
Characterisation of the NK cell response to HIPEC in high-grade serous Ovarian Cancer

Clinical Trial Fellowship

Dr Grisma Patel, University College London
Transforming oncology trials: Using big data for better outcomes

 

May 2024

Senior Cancer Research Fellowship

Dr Bethan Psaila, University of Oxford
Combating Cancer in a Challenging Environment – The Malignant Bone Marrow Niche

Advanced Clinician Scientist Fellowship

Dr Richard Mair, Cancer Research UK Cambridge Institute
Identifying the mechanisms responsible for low- to high-grade transformation in IDH mutant astrocytoma

Career Development Fellowship

Dr Heather Machado, University of Cambridge
Somatic evolution of CD8+ T cell tumour recognition, immune remodelling and immunotherapy response

Dr Haiyan Zheng, University of Bath
STEEP: Statistically Efficient Methods for Precision Medicine Trials

Pre-doctoral Research Bursary

Dr Kishen Patel, University College London
Integrating ctDNA Whole Genome Sequencing with Volumetric Analysis in Stage 3 Non-small cell lung cancer: A Proof-of-Concept Study

Postdoctoral Research Bursary

Dr Meera Patel, University of Manchester
Determining the role of bacteria in peritoneal metastasis from colorectal cancer

 

November 2023

Career Establishment Award

Dr Zarnie Khadjesari, University of East Anglia
Preventing cancer and cancer disparities with weight-management support – using hospital patient records and electronic signposting (eSIGN)

Dr Luigi Ombrato, Queen Mary University of London
Controlling metastasis formation by inhibiting the crosstalk between different myeloid cells

Dr Nischalan Pillay, University College London
Neo-Sarc: Enhancing the clinical whole genome sequencing programme for patients with genomically complex sarcomas

Career Development Fellowship

Dr Matthew Coelho, Wellcome Sanger Institute
Establishing the Genetic Landscape of Therapy Resistance in Lung Cancer with Gene Editing

Dr Anke Nijhuis, Imperial College London
Targeting RNA splicing as a novel therapeutic strategy in ovarian cancer

Dr Johan Vande Voorde, University of Glasgow 
Leveraging microbial metabolism to improve clinical outcome in colorectal cancer

Pre-doctoral Research Bursary

Dr Thineskrishna Anbarasan, University of Oxford
Integrating Spatial Transcriptomics with Multiparametric MRI in Prostate Cancer

Dr Faiz Jabbar, Imperial College Healthcare NHS Trust
Investigating how non-mutagenic factors influence driver gene selection during cancer initiation

Dr Thurkaa Shanmugalingam, King's College London
Profiling circulating tumour cells in lobular breast cancer

Dr Daniel Hughes, University College London
Modelling chromosome 13 deletion in human myeloma cell lines for functional assessment

Postdoctoral Research Bursary

Dr Oliver Pickles, University of Birmingham
Establishing a Patient-Derived Explant (PDE/PDTF) Programme for Colorectal Cancer Liver Metastases to Enhance Responses to Immune Checkpoint Blockade

 

May 2023

Senior Cancer Research Fellowship

Dr Ivana Bjedov, University College London
Defining novel mechanisms of selective radioprotection to improve cancer radiotherapy

Dr Andrew Blackford, University of Oxford
Genetic and functional interactions of RecQ helicases in cancer

Advanced Clinician Scientist Fellowship

Dr Amaya Viros, Cancer Research UK Manchester Institute
Melanoma metabolic programmes of metastasis, tropism and immunotherapy response by anatomic site

Career Establishment Award

Dr Mirjana Efremova, Queen Mary, University London
Characterising the cellular state transitions mediating colorectal cancer metastasis

Pre-doctoral Research Bursary

Dr Khaylen Mistry, University of East Anglia
Molecular characteristics and outcomes of melanoma in England: a national cohort study

Dr Riccardo Masina, University of Cambridge
Modelling drug response with multi-omics using machine learning in PDTC high-throughput drug screening

Dr Daniele Scotto, University of Nottingham
Characterisation of myeloid-derived suppressor cells as a therapeutic target in glioblastoma multiforme

Dr Georgios Solomou, Cambridge University Hospitals NHS Trust
Delineating glioblastoma cell state transitions during cell invasion using a patient-derived glioblastoma ex vivo organoid model (GBO)

Postdoctoral Research Bursary

Dr Thomas Hubbard, University of Exeter
Investigating the changes in breast cancer post neoadjuvant chemotherapy with Raman Spectroscopy

Dr Akshay Patel, University of Birmingham
Investigating Regulatory B cells as determinants of immune-related adverse events following checkpoint blockade therapy

Dr Robert Morgan, University of Manchester
Exploiting a Living Biobank to develop targeted therapies for platinum-resistant ovarian cancer

 

November 2022

Career Establishment Award

Dr Barrie Peck, Queen Mary, University of London
Understanding and exploiting Acetyl-CoA metabolism in Small Cell Lung Cancer

Senior Cancer Research Fellowship

Dr Jörg Mansfeld, Institute of Cancer Research
Discovery and functional investigation of how ROS can regulate the cell cycle

Clinician Scientist Fellowship

Dr Ayesha Noorani, Wellcome Sanger Institute 
Mapping the clonal dynamics and somatic mutations of the human oesophagus during disease, development and carcinogenesis

Dr Sung Pil Hong, Imperial College London
Single-cell multi-omic profiling of intratumoral heterogeneity to tackle oesophageal cancer cell adaptation to chemotherapy

Dr Gurdeep Mannu, University of Oxford
Pre-invasive and Invasive breast cancer: from risk factors to optimal treatment