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A trial looking at crizotinib for breast and stomach cancer (ROLo)

Overview

Cancer types:

Breast cancer, Secondary cancers, Stomach cancer

Status:

Closed

Phase:

Phase 2

Details

This trial is for people with advanced breast or stomach cancer. This means that the cancer:

  • has come back in the same place after treatment (local recurrence)

  • has spread to other parts of the body (metastatic)

It is for people who have had at least 1 type of treatment for advanced cancer.

To take part with breast cancer, you must have cells that are sensitive to the hormone oestrogen (oestrogen receptor positive or ER positive). And must not have receptors for a protein called HER2 (HER2 negative).

People with stomach cancer must have a rare type called diffuse stomach cancer (also known as signet cell cancer).

Everyone taking part must be E-cadherin negative. Your doctor can tell you more about this.

Recruitment start: 13 May 2019

Recruitment end: 30 November 2023

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Alicia Okines

Supported by

The Royal Marsden NHS Foundation Trust

Last reviewed: 30 November 2023

CRUK internal database number: 16382

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