Fulvestrant (pronounced full-vest-rant) is also called Faslodex. It is a treatment for breast cancer.
What is fulvestrant?
Fulvestrant is a hormone treatment for
Sometimes it is used in pre menopausal women with another treatment called a luteinising hormone releasing hormone agonist such as palbociclib or abemaciclib.
How does fulvestrant work?
The female sex hormones oestrogen and progesterone stimulate some breast cancers to grow. These breast cancers are called hormone sensitive or hormone receptor positive.
Drugs that block the effects of these hormones can slow or stop the growth of breast cancer cells.
Fulvestrant stops oestrogen getting to the cancer cells by blocking oestrogen receptors and reducing the number of receptors the cancer cells have.
How do you have fulvestrant?
You have fulvestrant as an injection into the muscle (intramuscular) in your bottom.
How often do you have fulvestrant?
You have fulvestrant as cycles of treatment. This means you have the drug and then a rest for your body to recover. Each cycle is 28 days (4 weeks).
On cycle 1 you have injections on day 1 and day 15.
After cycle 1 you have injections on day 1 of each cycle.
You have two injections – one into each buttock. You can have it at your GP surgery. Your doctor or practice nurse gives you the injections. Each injection takes 1 to 2 minutes.
You carry on with treatment until it stops working, and the side effects aren’t too bad.
You might have blood tests before starting treatment and during your treatment. They check your general health and might check your levels of blood cells and other substances in the blood.
What are the side effects of fulvestrant?
We haven't listed all the side effects. It is very unlikely that you will have all of these side effects, but you might have some of them at the same time.
How often and how severe the side effects are can vary from person to person. They also depend on what other treatment you are having. For example, your side effects could be worse if you are also having other drugs or radiotherapy.
When to contact your team
Your doctor or nurse will go through the possible side effects. They will monitor you closely during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:
- you have severe side effects
- your side effects aren’t getting any better
- your side effects are getting worse
Common side effects
These side effects happen in more than 10 in 100 people (more than 10%). You might have one or more of them. They include:
Tiredness and weakness (fatigue)
You might feel very tired and as though you lack energy.
Various things can help you to reduce tiredness and cope with it, for example exercise. Some research has shown that taking gentle exercise can give you more energy. It is important to balance exercise with resting.
Feeling or being sick
Feeling sick is usually mild. Anti sickness tablets can control it if you need them. Tell your doctor or nurse if you feel sick.
Hot flushes and sweats
We have some tips for coping with hot flushes and the possible treatments for men and women. Talk to your doctor if your hot flushes are hard to cope with. They might be able to prescribe you some medicines.
Soreness and swelling around the injection site
Tell your nurse if you notice any signs of redness or irritation around the injection site. Rarely you might have some bleeding or bruising at the injection sites.
This can last for 1 or 2 days after the injections.
You might have liver changes that are usually mild and unlikely to cause symptoms. They usually go back to normal when treatment finishes. You have regular blood tests to check for any changes in the way your liver is working.
Rarely you might have liver problems that change how well your liver is working.
Skin problems include a skin rash, dry skin and itching. This usually goes back to normal when your treatment finishes. Your nurse will tell you what products you can use on your skin to help.
You might have an allergic reaction when taking this drug. Symptoms can include a skin rash, itching, flushing, breathing problems, swelling of the face and throat and dizziness because of a low blood pressure. Rarely, some allergic reactions can be life-threatening.
Tell your nurse or doctor straightaway if you notice any of these symptoms or go straight to accident and emergency (A&E) if you have a reaction.
You might have pain in the muscles, back, bones, ligaments, tendons and nerves. Less commonly you might have pain along the sciatic nerve (Sciatica).
Occasional side effects
These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). You might have one or more of them. They include:
- loss of appetite
- increased risk of blood clots that can be life threatening; signs are pain, redness and swelling where the clot is. Feeling breathless can be a sign of a blood clot in the lung. Contact your advice line or doctor straight away if you have any of these.
- urine infection – you might have smelly urine, pain when passing urine or needing to pass urine more often
- vaginal bleeding, discharge, or a vaginal yeast infection (thrush)
- bruising, bleeding gums or nosebleeds
- numbness or tingling in your fingers or toes
What else do I need to know?
Other medicines, foods and drink
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
This drug contains very small amounts of alcohol. This is not harmful to most people but may be harmful if you have alcohol problems.
Loss of fertility
It is not known whether this treatment affects fertility in people. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
It is not known whether this drug comes through into the breast milk. Doctors usually advise that you don’t breastfeed during this treatment.
Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
More information about this treatment
For further information about this treatment go to the electronic Medicines Compendium (eMC) website.
You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.