Hodgkin lymphoma incidence statistics

Cases

New cases of Hodgkin lymphoma, 2015, UK

 

Proportion of all cases

Percentage Hodgkin lymphoma is of total cancer cases, 2015, UK

 

Age

Peak rate of Hodgkin lymphoma cases, 2013-2015, UK

 

Trend over time

Change in Hodgkin lymphoma cancer incidence rates since the early 1990s, UK

Hodgkin lymphoma is not among the 20 most common cancers in the UK, accounting for less than 1% of all new cancer cases (2015).[1-4]

In males in the UK, hodgkin lymphoma is the 19th most common cancer (less than 1% of all new male cancer cases). In females in the UK it is not among the 20 most common cancers (less than 1% of all new female cancer cases).

57% of hodgkin lymphoma cases in the UK are in males, and 43% are in females.

Hodgkin lymphoma incidence rates (European age-standardised (AS) rates Open a glossary item ) are similar to the UK average in all the UK constituent countries.

Hodgkin Lymphoma (C81), Number of New Cases, Crude and European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2015

  England Scotland Wales Northern Ireland UK
Male Cases 1,033 73 62 35 1,203
Crude Rate 3.8 2.8 4.1 3.8 3.8
AS Rate 4.0 2.9 4.1 4.1 3.9
AS Rate - 95% LCI 3.7 2.2 3.1 2.8 3.7
AS Rate - 95% UCI 4.2 3.6 5.1 5.5 4.1
Female Cases 749 74 57 27 907
Crude Rate 2.7 2.7 3.6 2.9 2.7
AS Rate 2.7 2.7 3.6 2.8 2.8
AS Rate - 95% LCI 2.5 2.1 2.6 1.8 2.6
AS Rate - 95% UCI 2.9 3.3 4.5 3.9 2.9
Persons Cases 1,782 147 119 62 2,110
Crude Rate 3.3 2.7 3.8 3.3 3.2
AS Rate 3.3 2.8 3.8 3.4 3.3
AS Rate - 95% LCI 3.2 2.3 3.1 2.6 3.2
AS Rate - 95% UCI 3.5 3.2 4.5 4.3 3.4

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item  around the AS Rate Open a glossary item
 

For hodgkin lymphoma, like most cancer types, differences between countries largely reflect risk factor prevalence in years past.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2015, ICD-10 C81.

Last reviewed:

Hodgkin lymphoma incidence shows a clear bimodal age distribution, with the first peak in incidence rates in young adults, and the second peak in older males and females, with the highest incidence rates being in older people. In the UK in 2013-2015, on average each year almost 3 in 20 (13%) of new cases were in people aged 75 and over.[1-4

Age-specific incidence rates rise sharply during childhood and peak first in young adults aged 20-24. Rates then decrease until middle age before rising again to reach a second peak. The highest rates are in the 75 to 79 age group for males and the 20 to 24 age group for females.

Incidence rates are significantly higher in males than females in a number of (mainly older) age groups. The gap is widest at age 0 to 04, when the age-specific incidence rate is 6.7 times higher in males than females.

Hodgkin Lymphoma (C81), Average Number of New Cases per Year and Age-Specific Incidence Rates per 100,000 Population, UK, 2013-2015

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item  around the AS Rate Open a glossary item
 

For Hodgkin lymphoma, like most cancer types, incidence increases with age. This largely reflects cell DNA damage accumulating over time. Damage can result from biological processes or from exposure to risk factors. A drop or plateau in incidence in the oldest age groups often indicates reduced diagnostic activity perhaps due to general ill health.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 2013-2015, ICD-10 C81.

Last reviewed:

Hodgkin lymphoma European age-standardised (AS) Open a glossary item incidence rates for males and females combined increased by 35% in the UK between 1993-1995 and 2013-2015.[1-4] The increase was of a similar size in males and females.

For males, Hodgkin lymphoma AS incidence rates in the UK increased by 32% between 1993-1995 and 2013-2015. For females, Hodgkin lymphoma AS incidence rates in the UK increased by 40% between 1993-1995 and 2013-2015.

Over the last decade in the UK (between 2003-2005 and 2013-2015), Hodgkin lymphoma AS incidence rates for males and females combined increased by 27%. In males AS incidence rates increased by 26%, and in females rates increased by 27%.

Hodgkin Lymphoma (C81), European Age-Standardised Incidence Rates, UK, 1993-2015

Hodgkin lymphoma incidence rates have increased overall in all broad age groups in males and females combined in the UK since the early 1990s.[1-4] Rates in 0-24s have increased by 21%, in 25-49s have increased by 17%, in 50-59s have increased by 21%, in 60-69s have increased by 45%, in 70-79s have increased by 108%, and in 80+s have increased by 134%.

Hodgkin Lymphoma (C81), European Age-Standardised Incidence Rates, By Age, UK, 1993-2015

For Hodgkin lymphoma, like most cancer types, incidence trends largely reflect changing prevalence of risk factors and improvements in diagnosis and data recording. Recent incidence trends are influenced by risk factor prevalence in years past, and trends by age group reflect risk factor exposure in birth cohorts.

References

  1. Data were provided by the Office for National Statistics on request, July 2017. Similar data can be found here: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/bulletins/cancerregistrationstatisticsengland/previousReleases.
  2. Data were provided by ISD Scotland on request, August 2017. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit, Health Intelligence Division, Public Health Wales on request, October 2017. Similar data can be found here: http://www.wcisu.wales.nhs.uk.
  4. Data were provided by the Northern Ireland Cancer Registry on request, July 2017. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for UK, 1993-2015, ICD-10 C81.

Last reviewed:

Staging for Hodgkin lymphoma most commonly uses the Ann Arbor system.[1]

Data by stage are not yet routinely available for the UK due to inconsistencies in the collecting and recording of staging data in the past. However this is improving and plans for a nationally consistent dataset in England are underway.[2] In the meantime, incidence by stage is available for the former Anglia Cancer Network in the east of England for the period 2004-2008.[3] Anglia covers around 5% of the population of England and may not be representative of the country as a whole due to differences in underlying demographic factors (such as age, deprivation or ethnicity), as well as variation in local healthcare provision standards and policies.

Over half (55%) of men and women diagnosed with Hodgkin lymphoma present at stage I or II.[3] For around a sixth (17%) of patients, the stage is not known.

Hodgkin Lymphoma (C81), Proportion of Cases Diagnosed at Each Stage, Adults (Aged 15-99), Former Anglia Cancer Network, 2004-2008

Stage at Diagnosis Proportion of cases
Stage I 24.4%
Stage II 30.8%
Stage III 15.4%
Stage IV 12.8%
Stage not known 16.7%

Percentages may not sum to 100 due to rounding

References

  1. Smithers DW. Summary of papers delivered at the Conference on Staging in Hodgkin's Disease (Ann Arbor). Cancer Res 1971; 31(11):1869-70.
  2. Department of Health. Improving outcomes: a strategy for cancer. London: Department of Health; 2011.
  3. Data were provided by The National Cancer Registration Service, Eastern Office on request.

About this data

Data is for: Former Anglia Cancer Network, 2004-2008, ICD-10 C81

Last reviewed:

Hodgkin lymphoma subtypes can be divided into two broad groups: Classical Hodgkin lymphoma (ICD-10 C81.1, C81.2, C81.3), which accounted for 60% of all Hodgkin lymphoma cases diagnosed in the UK in 2010-2012, and nodular lymphocyte-predominant Hodgkin lymphoma (ICD-10 C81.0), which accounted for 10% of cases. The remaining 29% of Hodgkin lymphoma cases in the UK in 2010-2012 were of other or unspecified Hodgkin lymphoma types (ICD-10 C81.7, C81.9).[1-4]

Hodgkin Lymphoma Subtypes, Annual Average Number of New Cases, European Age-Standardised (AS) Incidence Rates per 100,000 Population, UK, 2010-2012

  Classical Hodgkin lymphoma Nodular lymphocyte-predominant Hodgkin lymphoma Other and unspecified Hodgkin lymphoma
Male Cases 606 142 310
AS Rate (95% LCL-95% UCL) 2.0 (1.9-2.1) 0.5 (0.4-0.5) 1.1 (1.0-1.1)
Female Cases 513 51 234
AS Rate (95% LCL-95% UCL) 1.6 (1.6-1.7) 0.2 (0.1-0.2) 0.7 (0.7-0.8)
Persons Cases 1119 193 544
AS Rate (95% LCL-95% UCL) 1.8 (1.7-1.8) 0.3 (0.3-0.3) 0.9 (0.9-0.9)

95% LCL and 95% UCL are the 95% lower and upper confidence limits Open a glossary item around the AS Rate Open a glossary item

ASR calculated with ESP2013. Not comparable with ASRs calculated with ESP1976.

References

  1. Data were provided by the Office for National Statistics on request, July 2015. Similar data can be found here: http://www.ons.gov.uk/ons/rel/vsob1/cancer-statistics-registrations--england--series-mb1-/index.html
  2. Data were provided by ISD Scotland on request, April 2015. Similar data can be found here: http://www.isdscotland.org/Health-Topics/Cancer/Publications/index.asp.
  3. Data were provided by the Welsh Cancer Intelligence and Surveillance Unit on request, February 2015. Similar data can be found here: http://www.wales.nhs.uk/sites3/page.cfm?orgid=242&pid=59080
  4. Data were provided by the Northern Ireland Cancer Registry on request, March 2015. Similar data can be found here: http://www.qub.ac.uk/research-centres/nicr/.

About this data

Data is for: UK, 2010-2012, ICD-10 C81.0, C81.1, C81.2, C81.3, C81.7, C81.9

Last reviewed:

Hodgkin lymphoma incidence rates are projected to rise by 5% in the UK between 2014 and 2035, to 4 cases per 100,000 people by 2035.[1] This includes an increase for males and a drop for females.

For males, Hodgkin lymphoma European age standardised (AS) Open a glossary item incidence rates in the UK are projected to rise by 9% between 2014 and 2035, to 5 cases per 100,000 by 2035.[1] For females, rates are projected to fall by 1% between 2014 and 2035, to 3 cases per 100,000 by 2035.[1]

Hodgkin lymphoma (C81), Observed and Projected Age-Standardised Incidence Rates, by Sex, UK, 1979-2035

 

It is projected that 2,473 cases of Hodgkin lymphoma (1,480 in males, 993 in females) will be diagnosed in the UK in 2035.

References

  1. Smittenaar CR, Petersen KA, Stewart K, Moitt N. Cancer Incidence and Mortality Projections in the UK Until 2035. Brit J Cancer 2016.

About this data

Data is for: UK, 1979-2014 (observed), 2015-2035 (projected), ICD-10 C81

Projections are based on observed incidence and mortality rates and therefore implicitly include changes in cancer risk factors, diagnosis and treatment. It is not possible to assess the statistical significance of changes between 2014 (observed) and 2035 (projected) figures. Confidence intervals are not calculated for the projected figures. Projections are by their nature uncertain because unexpected events in future could change the trend. It is not sensible to calculate a boundary of uncertainty around these already uncertain point estimates. Changes are described as 'increase' or 'decrease' if there is any difference between the point estimates.

More on projections methodology

Last reviewed:

There is evidence for an association between Hodgkin lymphoma incidence and deprivation for males in England, but there is no evidence for an association for females.[1] England-wide data for 2006-2010 show European age-standardised  incidence rates are 20% higher for males living in the most deprived areas compared with the least deprived, but for females the rates are similar for those living in the least and most deprived areas.[1]

Hodgkin Lymphoma (C81), European Age-Standardised Incidence Rates by Deprivation Quintile, England, 2006-2010

For males diagnosed with Hodgkin lymphoma the deprivation gradient has gone from having higher incidence rates in the less deprived in 1996-2000 to having higher incidence rates in the more deprived in 2006-2010. The estimated deprivation gradient in Hodgkin lymphoma incidence between females living in the most and least deprived areas in England has not changed in the period 1996-2010.

It has been estimated that there would have been around 50 more cancer cases each year amongst males in England during 2006-2010 if all males experienced the same incidence rates as the least deprived.[1]

References

  1. Cancer Research UK and National Cancer Intelligence Network. Cancer by deprivation in England: Incidence, 1996-2010, Mortality, 1997-2011. London: NCIN; 2014.

About this data

Data is for UK, 2006-2010, ICD-10 C81

Deprivation gradient statistics were calculated using incidence data for 2006-2010. The deprivation quintiles were calculated using the Income domain scores from the Index of Multiple Deprivation (IMD) from the following years: 2004, 2007 and 2010. Full details on the data and methodology can be found in the Cancer by Deprivation in England NCIN report.

Last reviewed:

Age-standardised Open a glossary item rates for White males with Hodgkin lymphoma range from 2.7 to 3.0 per 100,000. Rates for Asian males are similar, ranging from 2.7 to 4.7 per 100,000 and the rates for Black males are also similar, ranging from 1.8 to 3.8 per 100,000. For females there is a similar pattern - the age-standardised rates for White females range from 1.9 to 2.2 per 100,000, and rates for Asian and Black females are also similar ranging from 1.6 to 2.9 per 100,000 and 1.3 to 2.7 per 100,000 respectively.[1] There appears to be no significant variation in Hodgkin lymphoma incidence by ethnicity in the UK.

Ranges are given because of the analysis methodology used to account for missing and unknown data. For Hodgkin lymphoma, 6,399 cases were identified; 17% had no known ethnicity.

Last reviewed:

An estimated 21,600 people who had been diagnosed with Hodgkin lymphoma between 1991 and 2010 were alive in the UK at the end of 2010.[1]

References

  1. Macmillan Cancer Support and National Cancer Registration and Analysis Service. Cancer Prevalence UK Data Tables. London: NCRAS; 2015.

About this data

Data is for: Great Britain (1991-2010) and Northern Ireland (1993-2010), ICD-10 C81

Last reviewed:

Around 17,600 new cases of Hodgkin lymphoma were diagnosed in Europe in 2012 (0.5% of total cancer cases). In Europe (2012), the highest World age-standardised Open a glossary item incidence rates for Hodgkin lymphoma are in Croatia for both men and women; the lowest rates are in Iceland for men and Albania for women. UK Hodgkin lymphoma incidence rates are estimated to be the 6th highest in males in Europe, and 20th lowest in females.[1] These data are broadly in line with Europe-specific data available elsewhere.[2]

Around 66,000 new cases of Hodgkin lymphoma were diagnosed worldwide in 2012 (0.5% of total cancer cases). Hodgkin lymphoma incidence rates are highest in Northern America and lowest in Eastern Asia, but this partly reflects varying data quality worldwide.[1]

Variation between countries may reflect different prevalence of risk factors, use of screening and diagnostic methods.

References

  1. Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al.Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. European Journal of Cancer (2013) 49, 1374-1403.
  2. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2013. Available from: http://globocan.iarc.fr, accessed December 2013.

About this data

Data is for Europe and Worldwide, 2012, ICD-10 C81

Last reviewed:

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