
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
This trial is looking at adding an early dose of local anaesthetic nerve block to the pain treatment for people having surgery for lung cancer.
It is for people having to remove their lung cancer.
Surgery is a common treatment for lung cancer. Because it works well, people who are older and have other health conditions can have this surgery. Good pain treatment is important. It helps to get people moving afterwards to prevent serious chest infections and to get better sooner.
The surgeon might choose to remove lung cancer using keyhole surgery.
At the end of surgery, it is routine for the doctor to inject some in the lining of the lung, near the nerves to your wound. This is called a paravertebral block. It numbs the pain and makes you more comfortable after surgery.
Recent research suggests that having a local anaesthetic dose before the surgery might reduce pain even more than just a dose after surgery. But this hasn’t been looked at in people having a paravertebral injection for lung cancer surgery. The researchers chose to find out more about this treatment in people having keyhole surgery. This type of surgery aims to improve recovery.
In this trial, some people have the nerve block with a local anaesthetic drug. And some have the nerve block with saline (a solution of salt and water) which has no numbing effect ().
The aim of the trial is to find out if combining a paravertebral block before and after surgery improves pain relief and recovery.
The following bullet points list the entry conditions for this trial. Talk to your doctor or the research team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this trial if all of the following apply. You:
Who can’t take part
You cannot join this trial if any of these apply. You:
The trial is taking place at Guy's and St Thomas' Hospitals Trust in London. The researchers need about 100 people to take part.
This is a randomised trial. There are 2 treatment groups. You are put into a group by a computer. Neither you nor your doctor will be able to tell which group you are in.
You have 1 of the following before surgery starts:
Before surgery you have a general anaesthetic so you can't feel anything during the operation. This sends you into a deep sleep.
The anaesthetist then uses an to see the exact place in the lining of the lungs to inject the nerve block. Depending on which group you are in you have either the local anaesthetic or the
injection.
The surgery then goes ahead as planned and the surgeon removes the cancer.
At the end of surgery, everyone has another paravertebral block with local anaesthetic. This is routine. The doctor leaves a very thin tube in place. This tube is called a paravertebral catheter. This allows you to have numbing local anaesthetic directly into the area around the lung.
After surgery you have pain killers to help keep you comfortable. You will have them in the following ways, as:
Measuring pain
The research team ask you to rate your pain at regular time points after surgery. They collect this information for 2 days, and after you leave hospital at 3 and 6 months.
Your hospital care team look after you in the routine way to manage your pain so you can get up and move.
Your recovery
The research team see how you are getting on after surgery. They look at:
Quality of life
The research team will ask you to fill out a questionnaire that asks about side effects and how you’ve been feeling. This is called a quality of life study. You complete it:
You don’t have any extra hospital visits if you join this trial. Your surgeon will tell you more about your surgery and how long you can expect to be in hospital for.
After you go home the research team will phone you at 3 months and 6 months. They will ask you about:
The research team monitor you during surgery and afterwards. They are able to treat any side effects that are causing problems straight away.
The side effects of having a nerve block are mild. The most common includes having low blood pressure.
Some less common side effects (which get better quickly) include:
All these side effects can happen from the routine paravertebral block that you have at the end of chest surgery.
The research doctor will tell you about all the possible side effects of having the extra nerve block during surgery. And the possible side effects of surgery.
We have more information about having surgery for lung cancer.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Cheng Ong
Guy's and St Thomas' NHS Foundation Trust
European Society of Regional Anaesthesia and Pain Therapy (ESRA)
If you are having your lung cancer surgery at Guy’s Hospital in London and think you might be suitable to take part in this study you can contact the team to find out more.
You can contact them by email: Tapresearch@gstt.nhs.uk or phone: 020 7188 8070.
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”