A trial looking at tivantinib with erlotinib for non small cell lung cancer that has spread (MARQUEE)

Cancer type:

Lung cancer
Non small cell lung cancer
Secondary cancers




Phase 3

This trial looked at tivantinib and erlotinib for non small cell lung cancer that had got worse despite other treatment. It was for people with non squamous cell cancer, such as adenocarcinoma Open a glossary item or large cell carcinoma Open a glossary item.

The trial was open for people to join between 2011 and 2012. The team published the results in 2015.

More about this trial

Doctors may treat advanced non small cell lung cancer (NSCLC) with targeted treatments called called tyrosine kinase inhibitors (TKIs). They block signals which cancer cells need to divide and grow. 

When this trial was done, doctors were already using erlotinib to treat advanced lung cancer. They wanted to find out if having tivantinib (ARQ 197) as well would be useful.

Tivantinib is also a TKI, but it works in a different way to erlotinib.

The people taking part were put into a treatment group at random:

The main aim of this trial was to see if erlotinib and tivantinib helps people with advanced NSCLC more than erlotinib alone.

Summary of results

As part of our editorial policy, any trial information we write is checked externally before we put it on our website. The research team have published some results for this trial. But we have been unable to find anyone involved with the trial to check the summary for us. 

This means we are not able to include a plain English summary of the results on this page.

More information
There is more information about this trial in the link to the medical journal below.

Please note, the information we link to here is not in plain English. It has been written for healthcare professionals and researchers.

Phase III Multinational, Randomized, Double-Blind, Placebo-Controlled Study of Tivantinib (ARQ 197) Plus Erlotinib Versus Erlotinib Alone in Previously Treated Patients With Locally Advanced or Metastatic Nonsquamous Non–Small-Cell Lung Cancer 
G Scagliotti and others
Journal of Clinical Oncology, 2015. Volume 33, issue 24, pages 2667 – 2676.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Conrad Lewanski

Supported by

ArQule Inc
Daiichi Sankyo
Experimental Cancer Medicine Centre (ECMC)

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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