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A trial of R-CHOP and acalabrutinib for people with Richter’s syndrome (STELLAR)

Overview

Cancer types:

Blood cancers, Chronic leukaemia, Chronic lymphocytic leukaemia (CLL), High grade lymphoma, Leukaemia, Lymphoma, Non-Hodgkin lymphoma (NHL)

Status:

Open

Phase:

Phase 2

Details

This trial is looking at acalabrutinib to see if it can improve treatment for people with Richter’s syndrome.

Chronic lymphocytic leukaemia (CLL) can sometimes develop into a condition called Richter’s syndrome. Richter's syndrome is a type of non-Hodgkin lymphoma (NHL).

Recruitment start: 23 July 2019

Recruitment end: 31 December 2025

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Toby Eyre

Supported by

Blood Cancer UK

Trials Acceleration Program (TAP)

Acerta Pharma

University of Birmingham

Last reviewed: 14 July 2025

CRUK internal database number: 16164

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