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A trial of pembrolizumab before surgery for bowel cancer (NEOPRISM-CRC)

Overview

Cancer types:

Bowel (colorectal) cancer, Colon cancer, Rectal cancer

Status:

Open

Phase:

Phase 2

Details

This trial is looking to see if having pembrolizumab before surgery improves treatment for bowel cancer that has a high risk of coming back.

It is for people who:

  • are going to have surgery to remove their cancer and

  • have certain gene changes () in their cancer cells

Recruitment start: 20 July 2022

Recruitment end: 31 March 2026

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Kai-Keen Shiu

Supported by

Cancer Research UK & UCL Cancer Trials Centre

Merck, Sharp & Dohme

University College London (UCL)

Last reviewed: 9 July 2025

CRUK internal database number: 18561

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