This is an international
phase 2 trial. Researchers need around 325 people from Europe to take part.
This trial is in 2 parts. First, you go into part 1 and you might be able to join part 2 afterwards.
Part 1 (standard treatment)
Everyone has the standard treatment. The 1st part of the standard treatment is chemoradiotherapy. You have:
- 4 treatment cycles of chemotherapy with etoposide and cisplatin or carboplatin
- radiotherapy twice a day for 3 weeks or radiotherapy once a day for 6 weeks
You then have prophylactic cranial irradiation (PCI). You have 10 radiotherapy treatments (fractions) in total.
Your doctor can tell you more about the standard treatment. It takes around 3 months in total.
After treatment, you have a
CT scan. Doctors want to find out how well the standard treatment worked. You:
- go into the 2nd part of the trial if your cancer stayed the same or got better
- stop the trial if your cancer got worse (your doctor will tell you which other treatments you might be able to have if this happens)
Part 2
This part of the trial is
randomised. Everyone taking part is put into 1 of the following groups by computer:
- nivolumab and ipilimumab (experimental arm)
- no more treatment (observation arm)
Neither you nor your doctor are able to decide which group you are in.
You have nivolumab as a
drip into a vein. It takes about 30 minutes each time you have it. You have it:
- every 3 weeks for 9 weeks
- then every 2 weeks for up to a year
You also have ipilimumab as a drip into a vein. You have it every 3 weeks for 9 weeks. It takes about 90 minutes each time you have it.
You have no further treatment if you go into the observation group. Your doctor will see you regularly to check how you are.
Blood tests
You have extra blood tests as part of this trial. Researchers want to look at the levels of certain proteins (
biomarkers 
) that can tell how well the treatment is working.
You have the extra blood tests before the start of treatment and at set times during the trial.
The research team might also ask you to have blood tests for future research studies. You don’t have to agree to this if you don’t want to. You can still take part in this trial.
Tissue sample
The trial team might ask to use a tissue sample of your cancer taken when you were diagnosed. Researchers want to store your tissue sample and use it in the future studies to learn more about lung cancer.
They may also ask you to have a
biopsy 
if your cancer gets worse. You don’t have to agree to this if you don’t want to. You can still take part in this trial.