A trial of nab-paclitaxel with CC-486 and durvalumab for advanced non small cell lung cancer

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.

You may be able to join this trial if all of the following apply. You:

• Have advanced non small cell lung cancer (NSCLC)  
• Have had a scan  such as a CT scan that shows at least 1 area of cancer that can be measured
• Have already had 1 course of treatment that included a platinum chemotherapy drug  such as cisplatin or carboplatin for your advanced NSCLC 
• Have satisfactory blood test results
• Are able to do everything apart from heavy physical work (performance status 0 or 1)
• Are willing to use reliable contraception for a month before starting treatment, during treatment and for up to 6 months afterwards if there is any chance you or your partner could become pregnant
• Are at least 18 years old

You cannot join this trial if any of these apply. You:

Cancer related

• Have NSLC  that is a squamous cell type
• Have cancer spread to the brain unless it has been treated, there are no symptoms and have had a scan that shows the spread has been stable for at least 8 weeks after treatment
• Have a known change (mutation) in the EGFR protein or the EML4-ALK gene

Medical conditions

• Have had another cancer in the past 5 years apart from some successfully treated early cancers
• Have moderate to severe nerve damage (peripheral neuropathy )
• Develop a blood clot within 1 month of starting treatment in the trial
• Have congestive heart failure
• Have had other heart problems such as a heart attack or severe angina in the past 6 months
• Have had high blood pressure in the past 6 months that hasn’t been controlled by medication
• Have had a stroke in the past 6 months
• Have a disorder that causes fits (seizures) in the past 6 months
• Have HIV, hepatitis B or hepatitis C
• Have an infection that needs treatment
• Have had lung diseases such as interstitial lung disease, sarcoidosis, silicosis, idiopathic pulmonary fibrosis or pulmonary hypersensitivity pneumonitis
• Have a disease that means you can’t absorb the necessary nutrients from your food such as Crohn’s disease, coeliac disease or lactose intolerance (a malabsorption syndrome)
• Have an ongoing problem with diarrhoea
• Are known to have a blockage in your bowel
• Have any other medical or mental health condition that could the trial team think could affect you taking part

Other

• Have already had a taxane drug
• Are currently taking part in another clinical trial or have had treatment with an experimental drug as part of a clinical trial in the past month
• Are taking medication that affects how your immune system   works
• Are sensitive to nab-paclitaxel, azacitidine, human albumin or mannitol
• Are pregnant or breastfeeding