
“I think it’s really important that people keep signing up to these type of trials to push research forward.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a new drug called LY2875358 for non small cell lung cancer which has spread to other parts of the body and has got worse despite having a drug called erlotinib. It is for people who have non small cell lung cancer with a change to a gene called MET.
Erlotinib is a type of biological therapy that doctors can use to treat lung cancer. But sometimes erlotinib stops working and the cancer can start to grow again. When this happens doctors say the cancer has become to the drug. Researchers are looking for new treatments to help people in this situation.
LY2875358 is a monoclonal antibody. These can seek out cancer cells by looking for particular proteins. In this trial researchers are looking to see if LY2875358 can help people whose cancer has stopped responding to treatment with erlotinib, and if LY2875358 can overcome resistance to the erlotinib.
The aims of this trial are to see
You may be able to enter this trial if you
You cannot enter this trial if you
This phase 2 trial will recruit about 100 people. It is a randomised trial. The people taking part are put into 2 treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.
People in 1 group have LY2875358 alone. People in the other group have LY2875358 and erlotinib. There will be 3 times as many people in the group having LY2875358 and erlotinib as in the group having LY2875358 alone.
You have treatment in 4 week periods called cycles of treatment.
You have LY2875358 as a drip into a vein on the1st and 15th day of each cycle. It takes 1½ hours each time.
If you are in the group having erlotinib, you take it as tablets every day.
You can have treatment
The trial team will ask you to fill out a questionnaire before you start treatment, at set times during the trial and when you stop treatment. The questionnaire will ask about side effects and how you’ve been feeling. This is called a quality of life study.
You see the trial team and have some tests before you start treatment.The tests include
To find out if you are suitable for the trial, the researchers need to make sure your cancer has a change to the MET gene. So they will send a sample of your cancer to the lab. This can be from a stored sample of cancer already collected from you after starting treatment with erlotinib. If there isn’t a sample of your cancer stored, you will need to have a new .
On the first day of each 4 week treatment cycle you have another physical examination, heart trace and urine test.
You have blood tests on the first day of each treatment cycle and then a week and 2 weeks later. You have a CT, PET or MRI scan every 6 weeks.
When you stop having the trial treatment you will have some more blood tests, a urine test, a heart trace and a physical examination.
You will meet with the trial doctor to discuss how you are. You then have a scan every 3 months until your cancer starts to grow again.
As LY2875358 is a new drug, there may be some side effects we don’t know about yet. Possible side effects include
The most common side effects of erlotinib include
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Denis Talbot
Eli Lilly and Company Limited
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
“I think it’s really important that people keep signing up to these type of trials to push research forward.”