A trial of cyclophosphamide, dexamethasone and ixazomib for myeloma (MUK 8)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers




Phase 2

This trial is for people whose myeloma has come back or treatment has stopped working.

More about this trial

Cyclophosphamide and the steroid drug dexamethasone are often used to treat myeloma. You might have these 2 drugs on their own or alongside 1 of the following

But if the myeloma comes back or doesn’t go away afterwards, it can be more difficult to treat. 

In this trial researchers are looking at a new drug called ixazomib alongside cyclophosphamide and dexamethasone. 

Ixazomib is a type of biological therapy Open a glossary item. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow.

The aims of the trial are to

  • find out if ixazomib helps people with myeloma
  • learn more about the side effects

Who can enter

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

You might be able to join this trial if all of the following apply. You

  • Have myeloma that has stopped responding to treatment or got worse after the last treatment 
  • Have myeloma that shows up in blood test and urine tests
  • Have had thalidomide, lenalidomide and a type of targeted drug called a proteasome inhibitor,  Open a glossary itemsuch as bortezomib, in the past
  • Your doctor thinks cyclophosphamide and dexamethasone is a suitable treatment for you
  • Are well enough to be up and about for at least half the day (performance status 0,1 or 2)
  • Have satisfactory blood test results
  • Are at least 18 years old
  • Are willing to use reliable contraception during treatment and for a minimum of a month and a half afterwards if there is any chance that you or your partner could become pregnant

You cannot join this trial if any of these apply.

  • You have a collection of white blood cells called plasma cells (a plasmacytoma) growing outside your bones and you have no other symptoms of myeloma or you have plasma cell leukeamia
  • You have myeloma in the brain or spinal cord
  • You have already had ixazomib 
  • Your kidneys aren’t working properly
  • You have problems with your heart, such as a heart attack in the last 6 months, high blood pressure that is not well controlled, angina that is not well controlled, an abnormal rhythm of your heart, congestive heart failure that is causing symptoms (fluid around you heart) 
  • You have had a stem cell transplant Open a glossary item with somebody else’s cells in the last 12 months
  • You have a condition called a graft versus host disease Open a glossary item 
  • You are known to be sensitive or allergic to ixazomib
  • You can’t swallow tablets or you have had problems with your digestive system Open a glossary item that might interfere with how you absorb the trial drug
  • You have had moderate to severe numbness or tingling in your hands and feet (peripheral neuropathy)
  • You have had radiotherapy for pain control in the 7 days before joining the trial 
  • You have had major surgery in the 2 weeks before joining the trial
  • You have taken any medication that blocks an enzyme called CYP3A4 or medications such as ciprofloxacin in the 7 days before joining this trial
  • You are known to be HIV positive 
  • You have an active infection including hepatitis A, hepatitis B or hepatitis C 
  • You have had any other cancer in the past unless it was successfully treated with surgery and there hasn’t been any sign of it since
  • You have any other medical condition or mental health problem that the trial team think would affect you taking part in this trial
  • You are pregnant or breast feeding

Trial design

This is a phase 2 trial. The researchers need 250 people to take part.

It is a randomised trial. You are put into 1 of 2 treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in.

  • one group have cyclophosphamide and dexamethasone
  • the other group have ixazomib, cyclophosphamide and dexamethasone

Diagram showing trial design for MUK 8

Dexamethasone, cyclophosphamide and ixazomib are tablets. You have treatment as follows in 4 week cycles (28 days). 

Cyclophosphamide and dexamethasone (CD)
You have

  • cyclophosphamide once a week for the first 3 weeks
  • dexamethasone tablets on 4 days a week for the first 2 weeks

Ixazomib, cyclophosphamide and dexamethasone (ICD)
You have

  • ixazomib and cyclophosphamide once a week for the first 3 weeks
  • dexamethasone tablets on 4 days a week for the first 2 weeks

You have treatment for as long it is helping you and the side effects aren’t too bad. 

You stop treatment if your myeloma gets worse. If you were having ICD, your doctor will talk to you about other treatment options. If you are having cyclophosphamide and dexamethasone, you might then be suitable to have ixazomib, cyclophosphamide and dexamethasone (ICD). But the trial doctor can tell you more about this. 

Research samples
The researchers will ask for a sample of your bone marrow which will be removed when you have your bone marrow test. The researchers will also ask to take extra blood tests as part of this trial. Where possible you have these at the same time as your routine blood tests. The aim of these tests is to understand more about myeloma and how to treat it. 

You don’t have to give these extra samples if you don’t want to. You can still take part in the trial.

Quality of life
The trial team will ask everybody taking part to complete some questionnaires before treatment starts and then regularly throughout treatment. These are called quality of life questionnaires. They look at how the treatment affects you physically and emotionally.

Hospital visits

You will see the trial doctors and have some tests before you start treatment. These include

While you are having treatment you go to hospital once a week for the first month. If you stop treatment and start another treatment, you are monitored by your doctor at follow up visits every month.

You might have more hospital visits than you had during your previous treatments. You see the doctors regularly for a physical examination and blood and urine tests. 

Your doctor might decide to stop your treatment if you have bad side effects. If this applies to you, you go to hospital every month for a check up.

Side effects

As ixazomib is a new drug, there might be side effects that we don’t know about yet. The trial team will monitor you during the time you have treatment and you will be given a phone number to call them if you are worried about anything. 

The most common side effects so far include

  • a drop in blood cells causing an increased risk of infection, bleeding problems, tiredness and breathlessness
  • skin rash
  • tiredness (fatigue)
  • feeling or being sick
  • diarrhoea or constipation
  • dehydration Open a glossary item
  • numbness, tingling or pain feelings in hands or feet (peripheral neuropathy)
  • fever and chills
  • taste changes and loss of appetite
  • kidney problems
  • headache
  • lung infections
  • shortness of breath and cough
  • tummy (abdomen) or back pain
  • swelling or fluid build up in the arms or legs
  • muscle, joint or bone aches and pains
  • feeling dizzy and low blood pressure

You mustn’t take certain drugs while taking part in this trial. These include St John’s Wort and ginkoba. The trial team will give you more information about this.

We have information about 

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Professor Gordon Cook

Supported by

Experimental Cancer Medicine Centre (ECMC)
Myeloma UK
NIHR Clinical Research Network: Cancer
Takeda Oncology
University of Leeds

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Over 60,000 cancer patients enrolled on clinical trials in the UK last year.

Last reviewed:

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