A trial of CCS1477 for some types of blood cancer

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if you have 1 of the following types of blood cancer that have come back or treatment has stopped working:

• B cell non-Hodgkin lymphoma
• T cell non-Hodgkin lymphoma
• myeloma 
• acute myeloid leukaemia (AML)
• high risk myelodysplastic syndrome (MDS)

As well as the above the following must also apply. You:

• have had at least 2 different standard treatments  for blood cancer in the past. You might be able to take part if there are no standard treatments available or you wouldn’t be suitable to have them. 
• are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
• have satisfactory blood test results 
• are willing to use reliable contraception during treatment and for 3 months afterwards if you or your partner could become pregnant. You are willing to use a condom during treatment and for 1 week after if you are a man and can pass your sperm to another person. 
• are at least 18 years old 

Who can’t take part

You cannot join this trial if any of these apply. You:

• have lymphoma in the brain or spinal cord, cancer that has spread to the tissue that covers the brain or spinal cord or a condition called spinal cord compression
• have had chemotherapy, an anti cancer drug, an immunotherapy  or an experimental treatment in the last 14 days or a treatment that hasn’t completely cleared your body 
• have had radiotherapy to more than 30% of the bone marrow within 4 weeks of trial treatment or in the last 2 weeks before you start treatment if you had radiotherapy to help with symptoms (palliative radiotherapy)
• have had another cancer in the past apart from non melanoma skin cancer  or carcinoma insitu (CIS ) that has been successfully treated. Or you had treatment for another cancer with the aim to cure it and there have been no signs of it for at least 6 months. 

Medical conditions
You:

• have had major surgery within 4 weeks of starting trial treatment 
• take more than 10mg of prednisolone each day or a similar drug and dose and you have had this within 2 weeks of starting trial treatment 
• have side effects from past treatments that aren’t getting better unless they are mild apart from hair loss or moderate numbness and tingling in the hands or feet (peripheral neuropathy )
• have a heart or lung condition that is severe or isn’t well controlled with medication. For example, you have congestive heart failure that is causing problems, high blood pressure or angina that isn’t well controlled with medication 
• have a heart condition called a QT prolongation 
• take medication for high cholesterol (statins) that you can’t stop taking. You should never stop taking a medication without first talking to your doctor.
• have an active infection including hepatitis B, hepatitis C or HIV 
• have a medical condition that means you are more likely to have a bleed 
• have taken any medication that blocks an enzyme called CYP3A4 in the 4 weeks before joining this trial
• have taken herbal medicine in the 7 days before starting trial treatment or you have taken St John’s wort in the last month 
• have any other medical condition or mental health problem that the trial team think would affect you taking part in this trial

Other
You:

• have a severe allergy to CCS1477 or anything it contains
• are pregnant or breastfeeding