A trial of ATRA and chemotherapy for pancreatic cancer (STARPAC-2 or PRIMUS-005)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have ductal adenocarcinoma of the pancreas that was confirmed with a tissue sample (biopsy ) from the Precision Panc trial. Or you had recent surgery and you were diagnosed with locally advanced pancreatic cancer.
• have cancer that has spread to nearby tissues (locally advanced cancer ) just outside the pancreas and it isn’t possible to remove it with surgery
• have cancer that your doctor can measure on a scan 
• have had a CT scan and a PET-CT scan within 28 days of being put into a trial treatment group 
• have satisfactory blood test results 
• are willing to use reliable contraception during the trial and for a certain period after if there is any chance you or your partner could become pregnant
• can look after yourself but might not be able to do heavy physical work (performance status 0 or 1)
• are at least 16 years old 

Who can’t take part

Cancer related 
You cannot join this trial if any of these apply. You:

• have cancer that has spread elsewhere in the body 
• have already had treatment that reaches the whole body (systemic treatment ) for pancreatic cancer
• have or have had another cancer unless you had treatment and there have been no signs of it for at least 2 years. You can join if it was successfully treated non melanoma skin cancer , early bladder cancer, prostate cancer under active surveillance, or carcinoma in situ (CIS ) of the cervix 
• are taking part in another trial of an experimental drug or device or you took part in one in the 30 days before you start trial treatment

Medical conditions
You cannot join this trial if any of these apply. You:

• have numbness or tingling (peripheral neuropathy ) in your hands and feet unless it is mild 
• have HIV, an active hepatitis B or hepatitis C infection or you have any other infection that needs treatment 
• have had major surgery within 4 weeks of being put into a trial treatment group 
• have a connective tissue problem such as lupus . Your doctor will know about this. 
• have scarring of the lung, lung inflammation or shortness of breath that is getting worse
• have had a heart attack or a significant heart problem  in the last year. Your doctor checks your heart before you can take part. 
• have a condition called peripheral artery disease 
• are taking vitamin A supplements or any other medication you can’t have if you join this trial. The team check your medications before you can take part. 
• have any other medication condition or mental health problem that the trial team think will affect you taking part 

Other 
You cannot join this trial if any of these apply. You:

• have had a live vaccination  within 4 weeks of starting trial treatment 
• are allergic to any of the drugs in the trial or anything they contain. This includes an allergy to soya beans or peanuts. 
• are pregnant or breastfeeding