A trial looking at atezolizumab and cabozantinib for non small cell lung cancer that has spread (CONTACT 01)

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have NSCLC that has spread elsewhere in the body
• have cancer that got worse during or after having an immunotherapy  and chemotherapy that included a platinum drug . The team check which treatments you had and when you had them to see if you are suitable for the trial
• have an area of cancer the doctor can see and measure on a scan
• have a sample of tissue available for the trial team to do some tests on or you are willing to give a new sample
• are well enough to carry out all your normal activities but you might not be able to do heavy physical work (performance status of 0 or 1)
• have satisfactory blood test results
• are willing to use reliable contraception during the trial and for a period of time afterwards if there is a chance you or your partner could become pregnant
• are at least 18 years old 

Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have cancer that has spread to the brain and spinal cord unless it isn’t causing symptoms, has been treated and is stable
• have any other cancer or had another cancer in the last 3 years that needs treatment apart from non melanoma skin cancer , prostate cancer or carcinoma (CIS) of the prostate, cervix or breast that has been successfully treated
• have lung cancer with the EGFR or ALK gene change
• have had cabozantinib, docetaxel or another similar drug in the past
• have had an experimental drug in the last 28 days
• have pain caused by cancer that isn’t well controlled with medication
• have side effects from past treatments that aren’t getting better apart from hair loss or moderate numbness and tingling in your hands and feet 

Medical conditions 
You can’t join the trial if the following apply. You:

• have areas of fluid on the lung, heart or tummy that need frequent draining
• have severe liver damage
• have had a serious heart problem including a heart attack or a stroke within the last 6 months, you have an abnormal heart rhythm or another heart condition that needs treatment. The trial team check if you have a heart condition before you join the trial
• have had major surgery in the last 4 weeks or need to have major surgery soon
• have an autoimmune disease unless it is type 1 diabetes, hair loss (alopecia), thyroid problems that are controlled by medications or certain skin conditions that don’t need treatment
• have scarring on the lungs or active inflammation of the lungs (pneumonitis )
• have had a stem cell transplant  or an organ transplant
• have had treatment to stimulate the immune system  such as interferon in the last 2 weeks or this treatment hasn’t completely cleared your body
• have had treatment that damps down the immune system such as steroids within 2 weeks of starting trial treatments unless it was a low dose
• are taking drugs such as warfarin to thin your blood
• have had a blood clot in your leg or lung within 6 months of starting trial treatment 
• have high blood pressure that isn’t well controlled with medication
• have problems with your digestive system  such as areas of cancer, inflammatory bowel disease or a blocked bowel
• have areas of cancer that have grown into the blood vessels in the lungs
• have an increased risk of having a bleed or you had a big bleed in the last 3 months
• have a serious wound, ulcer or bone fracture that isn’t getting better
• have a problem absorbing nutrients
• have a lesion in the lung called a cavitating lesion or cancer in your airways causing breathing difficulties
• have a problem with your kidneys and need to have dialysis
• have HIV, an active hepatitis B or hepatitis C infection, tuberculosis (TB) or a recent severe infection that needed treatment
• can’t swallow tablets 

Other
You can’t take part if the following apply. You:

• have had a severe allergic reaction to atezolizumab, cabozantinib or docetaxel or anything they contain
• have had a live vaccine  in the last 4 weeks or might need one during the trial
• are pregnant or breastfeeding