A trial looking at pembrolizumab with radiotherapy for non small cell lung cancer (KEYNOTE-867)

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have non small cell lung cancer that measures less than 5cm across (stage 1 or stage 2)
• haven’t had treatment for your cancer
• can’t have surgery or you don't want surgery to remove your cancer
• can have stereotactic radiotherapy unless your cancer is very much in the centre of your chest
• can look after yourself and are up and about for half the day (performance status 0, 1 or 2)
• have satisfactory blood test results
• are willing to use reliable contraception during treatment and for 6 months after if there is any chance you or your partner could become pregnant
• are at least 18 years old 

Who can’t take part

You cannot join this trial if any of these apply. You:

• have had treatment that works in a similar way to pembrolizumab
• have had radiotherapy to the chest including the food pipe and breast
• have had a live vaccination  within 30 days before starting treatment
• have had an experimental drug or used an experimental device as part of another clinical trial within 4 weeks before starting treatment
• are taking steroids at a dose of more than 10mg a day or any other medication that damps down the immune system within 7days of starting treatment
• have had another cancer within the past 3 years that has got worse or needed treatment apart from successfully treated non melanoma skin cancer or any carcinoma in situ  for example breast and cervical
• are known to be allergic to pembrolizumab or any of its ingredients
• have inflammation of the lungs not caused by an infection (pneumonitis) or have had steroids to treat this in the past
• have had hepatitis B
• have an active infection of hepatitis C
• have or had an autoimmune disease in the past 2 years that needed treatment unless it was treatment to replace substances needed in the body for example hormone replacement for a thyroid gland that isn’t working well or insulin
• have an infection that needs treatment that reaches the whole body (systemic treatment )
• have HIV
• have had tuberculosis (TB)
• have any other medical condition or mental health problem that your doctor or the trial team think could affect you taking part in the trial
• are pregnant or breastfeeding
• have had a stem cell or bone marrow transplant from another person (allogenic transplant )
• have had a solid organ transplant  such as kidneys or liver