A trial looking at pembrolizumab combined with enzalutamide for prostate cancer (KEYNOTE 641)

Overview

Cancer types:

Prostate cancer

Status:

Results

Phase:

Phase 3

Details

This trial was for men with prostate cancer that had spread and was getting worse despite having hormone therapy or having their testicles removed. This is called metastatic castration resistant prostate cancer.

The trial compared pembrolizumab and enzalutamide with a dummy drug (placebo) and enzalutamide.

People could join the trial between 2019 and 2022. The team presented the results at the 2023 ESMO conference.

There is a link to more information in the ‘Summary of results’ section below.

Recruitment start: 21 August 2019

Recruitment end: 10 June 2022

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Johann De Bono

Supported by

Merck Sharp & Dohme LLC

Last reviewed: 10 Jul 2026

CRUK internal database number: 17103

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