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Enzalutamide (Xtandi)

Find out what enzalutamide is, how you have it and other important information about having enzalutamide.

Enzalutamide is a cancer treatment and is also known by its brand name, Xtandi.

It is a treatment for advanced prostate cancer.

How it works

Prostate cancer needs testosterone to grow.

Enzalutamide stops your body from making testosterone. This can slow the growth of the cancer and may shrink it. 

Enzalutamide is a hormone treatment. This group of drugs is called androgen receptor agonists. 

How you have it

You take enzalutamide as capsules, once a day. You swallow them whole with a glass of water. You can have the capsules with or without food.

Taking capsules

You must take capsules according to the instructions your doctor or pharmacist gives you.

You should take the right dose, not more or less.

Never stop taking a cancer drug without talking to your specialist first.

When you have it

Enzalutamide is used in the treatment of prostate cancer that has spread to other parts of your body. 

Enzalutamide might be used when:

  • other hormone treatments are no longer working for you
  • you have completed docetaxel chemotherapy

Tests during treatment

You might have blood tests before starting treatment and during your treatment. They check your general health and might check your levels of blood cells and other substances in the blood.

Side effects

Important information

Other medicines, foods and drink

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.


This drug may harm a baby developing in the womb. It is important not to father a child while you are having treatment with this drug and for at least 3 months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.


We don’t know how this treatment might affect fertility. You may not be able to father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.

Some men might be able to store sperm before starting treatment.

Treatment for other conditions

Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Sorbitol and enzalutamide

This medicine contains sorbitol (a type of sugar). If you have intolerance to some sugars, contact your doctor before taking this medicine.

More information about this treatment

For further information about this treatment go to the electronic Medicines Compendium (eMC) website.

You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.

Information and help

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