A trial looking at MK-2870 for non small cell lung cancer that has spread

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have locally advanced  NSCLC that can’t be removed with surgery or you can’t have radiotherapy with the aim to cure or you have cancer that has spread to another part of the body
• have certain gene changes in the EGFR gene in your lung cancer cells or changes in certain other genes. These include ROS1, BRAF V600E, NTRK or MET. Your doctor will check this. 
• have had certain treatment if you have a change in the EGFR gene called 19del or exon 21 in your lung cancer cells. This includes having at least 2 courses of treatment  with a targeted cancer drug called a tyrosine kinase inhibitor  and treatment that included a platinum drug . Your doctor checks if you have these gene changes and which treatments you’ve had in the past. 
• have had certain treatment if you have other gene changes in the lung cancer cells. This treatment includes having at least 2 courses of a tyrosine kinase inhibitor and treatment that included a platinum drug. Your doctor checks if you have these gene changes and which treatments you’ve had in the past.
• have lung cancer that got worse during or after your last treatment
• have cancer that your doctor can measure on a scan
• have a sample of tissue (biopsy ) available that the trial team can use to do some tests on or you are willing to have a new sample taken
• have satisfactory blood test results  
• are willing to use reliable contraception during the trial and for a time after if there is any chance you or your partner could become pregnant 
• are willing not to donate sperm during the trial and for a period after 
• are willing not to donate eggs to others or to freeze or store eggs if you join this trial 
• are fit and active but might not be able to do heavy physical work (performance status 0 or 1) 
• are at least 18 years old 

Who can’t take part

Cancer related 
You cannot join this trial if any of these apply. You:

• have cancer that has spread to the brain or spinal cord or the thin tissue layers that cover them. You can take part if you had treatment, the cancer is stable and you stopped taking steroids.
• have non small cell lung cancer that is mainly made up of squamous cells
• have a mixture of small cell and non small cell cancer cells 
• have had treatment with a drug that works in the same way as MK-2870
• have an EGFR gene change called T790M and you haven’t had a drug called osimertinib or a similar drug 
• have had radiotherapy to help with symptoms within a week of starting trial treatment. Any side effects from radiotherapy must be better and you can’t be taking steroids.
• have had radiotherapy to the lung that was more than 30Gy within 6 months of the first dose of trial treatment. Your doctor will know this. 
• have had another cancer treatment within 4 weeks of being put into a trial treatment group. Or it hasn’t cleared from your body yet .
• have another cancer that is getting worse or needed treatment in the last 3 years. You can take part if you had successfully treated basal cell skin cancer , squamous cell skin cancer  or early cancer of the bladder 
• are taking an experimental drug or using a device as part of another clinical trial. This is if it is within 28 days of being put in a treatment group for this trial.
• have moderate to severe side effects from past cancer treatments. This doesn’t apply if you have hair loss or white patches on your skin. 

Medical conditions
You cannot join this trial if any of these apply. You:

• have or had inflammation of the bowel and you are taking medication to damp down the immune system  
• have moderate to severe numbness or tingling in your hands or feet (peripheral neuropathy)
• have severe dry eyes, inflammation of the eyelids or a problem with the covering of your eye (cornea)
• have had a heart attack in the last 6 months or a significant heart problem  that needs treatment. The trial team check if you have a heart condition before you join the trial. 
• have had a stroke  in the last 6 months 
• take medication that affects substances in the body called CYP enzymes within 2 weeks of starting trial treatment. Your doctor can tell you more about this.
• have or had scarring on the lungs or active inflammation of the lungs (pneumonitis ) and you needed to have steroid treatment  
• have HIV unless you are having treatment and it is under control. You can’t take part if you have HIV and you developed an illness that occurs more often and is more severe in people with HIV.
• have active hepatitis B or hepatitis C unless you have had or are having treatment and it is under control or you have another active infection that needs treatment to the whole body 
• have had major surgery and you aren’t better yet 
• have any other medical condition or mental health problem that could affect you taking part 

Other 
You cannot join this trial if any of these apply. You:

• are allergic to MK-2870, anything it contains or any of the other treatments in the trial 
• have had a live vaccine  within 30 days of the start of treatment. Please note that the approved COVID-19 vaccines are allowed as they aren’t a live vaccine.
• have a problem with drugs or alcohol 
• are pregnant or breastfeeding