A trial looking at DTP3 for lymphoma or myeloma

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

For people who have myeloma the following must apply. You:

• have myeloma that is stage 1, stage 2 or stage 3 that needs to be treated
• have myeloma that the doctor can measure in a blood or urine test
• have myeloma that got worse after your last treatment or treatment stopped working 
• have already had treatment that included bortezomib, lenalidomide or thalidomide, daratumumab or similar drugs. You might be able to take part if you had only 2 of these treatments. Your doctor will talk to you about this.
• have had at least 2 different courses of treatment  in the past

For people who have diffuse large B cell lymphoma the following must apply. You:

• have diffuse large B cell lymphoma that needs treatment 
• have a type of lymphoma called non germinal large B cell lymphoma. This only applies to people joining the dose expansion group.
• have at least 2 areas of lymphoma that your doctor can see on a scan that measure more than 1.5cm in length. Or you have one area that measures more than 2cm in length.
• have no standard treatment  available to you
• have lymphoma that got worse after your last treatment or treatment stopped working 

As well as the above entry conditions for myeloma and lymphoma, the following must also apply. You:

• have satisfactory blood test results 
• are up and about more than half the day, you can look after yourself but might not be able to work (performance status 0, 1 or 2)
• are willing to use reliable contraception during the trial and for a period after if there is any chance you or your partner could become pregnant 
• are at least 16 years old 

Who can’t take part

Cancer related 
You cannot join this trial if any of these apply. You:

• have lymphoma of the brain or spinal cord
• have T-cell histiocyte-rich large B-cell lymphoma
• have a rare type of blood cancer called plasma cell leukaemia (plasma cell myeloma)
• have primary amyloidosis. Your doctor will know this. 
• have had treatment for myeloma or diffuse B cell lymphoma within 28 days of the first dose of DTP3. This doesn’t include having bisphosphonates.
• are suitable to have a stem cell transplant  or CAR T-cell therapy
• have had a stem cell transplant or CAR T-cell therapy within 12 weeks of joining the trial
• have taken part in another trial with an experimental drug within 28 days of joining this trial or you are having treatment with an experimental drug
• have had radiotherapy within 28 days or might need to have radiotherapy while you are taking part in this trial. You can take part if you are having radiotherapy to a single area to help with symptoms
• have had another cancer in the past. You can join if you had successfully treated non melanoma skin cancer , carcinoma in situ  of the cervix or early prostate cancer. You could join if you had another cancer in the last 3 years and there have been no signs of it since.

Medical conditions
You cannot join this trial if any of these apply. You:

• have had a heart attack, significant heart surgery in the last 6 months or any other heart problem  that needs treatment. The trial team check if you have a heart condition before you join the trial.
• have had a stroke or problems with reasoning, planning, judgment, memory and other thought processes (vascular dementia)
• have a condition called POEMS syndrome 
• have a risk of bleeding or you have a bleeding problem
• have moderate to severe tingling and numbness or pain in your hands and feet (peripheral neuropathy )
• are having treatment that damps down the immune system . This includes steroids unless it is a low dose or you are having them for a short time to control symptoms.
• have HIV, an active hepatitis B or hepatitis C infection
• have any other medical condition or mental health problem that the trial team think will affect you taking part 

Other
You cannot join this trial if you are pregnant or breastfeeding.