A trial giving radiotherapy again for glioblastoma (BRIOChe)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have a brain tumour called glioblastoma that has come back after your initial treatment. You can also join if your glioblastoma had come back once, you had surgery to remove it and no other treatment. 
• finished your initial radiotherapy at least 6 months ago 
• had at least 2 weeks of temozolomide with your initial radiotherapy
• had an MRI scan  using a contrast dye  to confirm the glioblastoma has come back within 3 weeks of going into a treatment group (randomisation )
• can look after yourself but might not be able to do all your usual activities or active work (Karnofsky performance status 70 to 100)
• have satisfactory blood test results
• are willing to use contraception during treatment and for a time after if you or your partner could become pregnant
• can swallow tablets and capsules
• are at least 18 years old

Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have cancer that has come back in the tissue surrounding the brain or spinal cord  
• have already had systemic treatment  such as chemotherapy for the glioblastoma that has come back
• have already had radiotherapy for glioblastoma that has come back
• have already had very high doses of radiotherapy to certain parts of the brain. Your doctor will know if you have.   
• only have glioblastoma that has come back that the contrast dye has not highlighted on the MRI scan. Your doctor will know about this. 
• have more than 3 areas where the glioblastoma has come back 
• have certain gene changes (mutations ) in your glioblastoma. Your doctor will know about this. 
• have had another cancer apart from non melanoma skin cancer . You can join if you have had treatment for another cancer and there has been no sign of it for at least a year. 
• are not able to have chemotherapy or radiotherapy 
• have ongoing side effects from previous treatment
• are taking part in another clinical trial using an experimental drug or device 

Medical conditions
You cannot join this trial if any of these apply. You:

• are not able to have an MRI scan with the contrast dye. This could be because you have metal such as surgical clips in your body or you are allergic to the dye. There are other reasons that your doctor will know about. 
• have an inherited  condition where your body is not able to absorb sugars such as lactose, galactose and glucogalactose. You also cannot join if you are allergic to these sugars. 
• have a disease that affects the spinal cord or the lower back part of the brain
• have another medical condition or mental health problem that could affect you taking part in the trial

Other
You cannot join this trial if any of these apply. You

• have had an allergic reaction to nitrosoureas
• are pregnant or breastfeeding