Procarbazine, lomustine (also known as CCNU) and vincristine is a combination of chemotherapy drugs. This is a treatment for a type of brain tumour called glioma.
What are procarbazine, lomustine and vincristine (PCV)?
Procarbazine, lomustine and vincristine are chemotherapy drugs.
Procarbazine is pronounced proh-KAR-buh-zeen. Lomustine is pronounced loh-MUS-teen and vincristine as vin-KRIS-teen.
This combination of chemotherapy drugs is a treatment for a type of brain tumour called glioma.
How do procarbazine, lomustine and vincristine (PCV) work?
These chemotherapy drugs destroy quickly dividing cells, such as cancer cells.
How do you have procarbazine, lomustine and vincristine (PCV)?
You have vincristine into your bloodstream (intravenously). You take lomustine and procarbazine as capsules.
Into your bloodstream
You might have treatment through a long plastic tube that goes into a large vein in your chest. The tube stays in place throughout the course of treatment. This can be a:
- central line
- PICC line
If you don't have a central line
You might have treatment through a thin short tube (a cannula) that goes into a vein in your arm each time you have treatment.
When taking lomustine and procarbazine capsules you swallow them whole with a full glass of water. You should not open, crush or chew the capsules.
Taking your capsules
Whether you have a full or empty stomach can affect how much of a drug gets into your bloodstream.
You should take the right dose, not more or less.
Talk to your specialist or advice line before you stop taking a cancer drug.
How often do you have procarbazine, lomustine and vincristine (PCV)?
You usually have procarbazine, lomustine and vincristine as cycles of treatment. This means that you have the drugs and then a rest to allow your body to recover.
Each cycle lasts about 42 days (6 weeks). You usually have up to 8 cycles. It might take around 12 months in total.
You might have each cycle of treatment in the following way:
- You take procarbazine capsules 3 times a day (some hospitals may give this on day 2 to 11).
- You have vincristine as a drip into your bloodstream (intravenously) over 10 minutes.
- You take lomustine as capsules at night.
- You have no treatment.
You then start a new cycle of treatment.
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
What are the side effects of procarbazine, lomustine and vincristine (PCV)?
How often and how severe the side effects are can vary from person to person. They also depend on what other treatments you're having. For example, your side effects could be worse if you're also having other drugs or radiotherapy.
When to contact your team
Your doctor, nurse or pharmacist will go through the possible side effects. They will monitor you closely during treatment and check how you are at your appointments. Contact your advice line as soon as possible if:
- you have severe side effects
- your side effects aren’t getting any better
- your side effects are getting worse
Early treatment can help manage side effects better.
We haven't listed all the side effects here. Remember it is very unlikely that you will have all of these side effects, but you might have some of them at the same time.
Common side effects
These side effects happen in more than 10 in 100 people (more than 10%). You might have one or more of them. They include:
Increased risk of infection
Increased risk of getting an infection is due to a drop in white blood cells. Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. You might have other symptoms depending on where the infection is.
Infections can sometimes be life threatening. You should contact your advice line urgently if you think you have an infection.
Bruising and bleeding
This is due to a drop in the number of platelets in your blood. These blood cells help the blood to clot when we cut ourselves. You may have nosebleeds or bleeding gums after brushing your teeth. Or you may have lots of tiny red spots or bruises on your arms or legs (known as petechiae).
You might be breathless and look pale due to a drop in red blood cells. This is called anaemia.
Lung changes may cause symptoms such as pain, tightness in the chest, wheezing or difficulty breathing.
Feeling or being sick
Feeling or being sick is usually well controlled with anti sickness medicines. Avoiding fatty or fried foods, eating small meals and snacks, drinking plenty of water, and relaxation techniques can all help.
It is important to take anti sickness medicines as prescribed even if you don’t feel sick. It is easier to prevent sickness rather than treating it once it has started.
You might feel very tired and as though you lack energy.
Various things can help you to reduce tiredness and cope with it, for example exercise. Some research has shown that taking gentle exercise can give you more energy. It is important to balance exercise with resting.
Tummy (abdominal) pain
Tell your treatment team if you have this. They can check the cause and give you medicine to help.
Difficulty opening your bowels (constipation)
Constipation is easier to sort out if you treat it early. Drink plenty of fluids and eat as much fresh fruit and vegetables as you can. Try to take gentle exercise, such as walking. Tell your doctor or nurse if you are constipated for more than 3 days. They can prescribe a laxative.
Numbness or tingling in fingers and toes
Numbness or tingling in fingers or toes is often temporary and can improve after you finish treatment. Tell your doctor if you're finding it difficult to walk or complete fiddly tasks such as doing up buttons.
Occasional side effects
These side effects happen in between 1 and 10 out of every 100 people (between 1 and 10%). You might have one or more of them. They include:
- hair loss – hair usually grows back once treatment has finished
- skin problems such as a rash
- changes to the way your liver works which are usually temporary – you have regular blood tests to check this
- loose or watery poo (diarrhoea)
- a sore mouth and ulcers
- pain in your jaw
- changes to the way your kidneys work – you have regular blood tests to check this
Rare side effects
These side effects happen in fewer than 1 in 100 people (less than 1%). You might have one or more of them. They include:
- a second cancer such as acute leukaemia or myelodysplastic syndrome some years after this treatment
- redness, swelling, pain or leaking at your drip site
- lung changes that can cause breathlessness and a cough
- confusion or disorientation
- difficulty in walking or speaking
- problems with your eyesight such as loss of vision
Other side effects
There isn't enough information to work out how often these side effects might happen. You might have one or more of them. They include:
- an allergic reaction that can cause a rash, shortness of breath, redness or swelling of the face and dizziness - some allergic reactions can be life threatening, alert your nurse or doctor if you notice any of these symptoms
- high blood pressure that might cause headaches, confusion, vision problems or chest pain
- low blood pressure that can cause you to feel lightheaded or dizzy
- problems with passing urine such as passing large amounts of urine, having discomfort when passing urine or not being able to pass urine (urine retention)
- stiff joints and muscle aches and pains
Coping with side effects
We have more information about side effects and tips on how to cope with them.
What else do I need to know
Other medicines, foods and drinks
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
Avoid drinking alcohol while having this treatment. It may cause a reaction. Symptoms include flushing in your face and neck, an increased body temperature, sweating, feeling and being sick, itching and a headache.
Procarbazine can interact with alcohol, non alcoholic beers and other foods which are not fresh. More so if they have been fermented, pickled, smoked ‘hung’ or ‘matured’. Some of the foods that could cause an interaction include:
- mature or processed cheeses
- yeast or meat extracts - such as Marmite, Oxo or Bovril
- salami and pepperoni
- overripe fruit
- wines and lagers
- fermented or pickled foods
Pregnancy and contraception
This treatment might harm a baby developing in the womb. It is important not to become pregnant or father a child while you're having treatment and for a few months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.
Loss of fertility
You may not be able to become pregnant or father a child after treatment with these drugs. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
Men might be able to store sperm before starting treatment. And women might be able to store eggs or ovarian tissue. But these services are not available in every hospital, so you would need to ask your doctor about this.
Don’t breastfeed during this treatment because the drugs may come through in your breast milk.
Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations.
In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and the shingles vaccine (Zostavax).
- have other vaccines, but they might not give you as much protection as usual
- have the flu vaccine (as an injection)
Contact with others who have had immunisations - You can be in contact with other people who have had live vaccines as injections. Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as the oral typhoid vaccine.
If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray. This is for 2 weeks following their vaccination.
Babies have the live rotavirus vaccine. The virus is in the baby’s poo for about 2 weeks and could make you ill if your immunity is low. Get someone else to change their nappies during this time if you can. If this isn't possible, wash your hands well after changing their nappy.
More information about this treatment
For further information about this treatment go to the electronic Medicines Compendium (eMC) website.
You can report any side effect you have to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.