Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
A trial for small cell lung cancer, looking at chemotherapy with or without pravastatin (LungStar)
This trial compared chemotherapy with and without a drug called pravastatin, for people with small cell lung cancer (SCLC). It was supported by Cancer Research UK.
More about this trial
Researchers are looking at other treatments people can have alongside chemotherapy. They hope they can improve the outcome for people with SCLC. In this trial they looked at pravastatin.
Pravastatin belongs to a group of drugs called statins, one of the treatments used to lower cholesterol. Laboratory research had shown that pravastatin may help chemotherapy for small cell lung cancer to work better. Researchers wanted to find out if having pravastatin and chemotherapy together is better than having chemotherapy alone.
The main aim of this trial was to find out if pravastatin and chemotherapy can help people with small cell lung cancer live longer.
Summary of results
- half had chemotherapy and pravastatin tablets
- half had chemotherapy and dummy (placebo) tablets
- 7.7 months for those who had pravastatin
- 7.3 months for those who had the placebo
- 10.7 months for those who had pravastatin
- 10.6 months for those who had the placebo
- a drop in blood cells
- tiredness (fatigue)
- shortness of breath
How to join a clinical trial
Professor M.J. Seckl
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
This is Cancer Research UK trial number CRUK/06/009.