This is a
phase 3 study. It is taking place worldwide. The researchers need 600 people to take including 30 from the UK.
Everyone has dabrafenib and trametinib. Dabrafenib is a capsule. Trametinib is a tablet.
You take:
- dabrafenib capsules twice a day, everyday
- trametinib tablets once a day, everyday
You have treatment for up to 1 year.
Managing a fever
The most common side effect of the combination of dabrafenib and trametinib is a fever. Take your temperature if you are feeling unwell. The study team will ask you to contact them if your temperature is 38°C or above. They will tell you what to do. They will follow the specific guidelines in the trial protocol to bring your temperature down to normal as quickly as possible. This might involve stopping treatment for a short time and taking some medication.
The study team will collect information about fevers, hospital stays and if you had to stop treatment and for how long.
If during the study your melanoma comes back you may have to stop treatment and your doctor will talk to you about other treatment options.
Quality of life
The study team will ask you to fill out a questionnaire before you start treatment and at set times during treatment. The questionnaire will ask about side effects and how you’ve been feeling. This is called a
quality of life survey 
.