Find out what dabrafenib is, how you have it and other important information about taking this drug.
Dabrafenib is a cancer treatment and is also known by its brand name Tafinlar.
It is used as a treatment for melanoma skin cancer. You might have dabrafenib if your melanoma has spread to other parts of the body or can't be removed with surgery.
How it works
Dabrafenib is a cancer growth blocker. It stops signals that cancer cells use to divide and grow.
In some cancers there is a change (mutation) in a gene called BRAF. The BRAF gene makes a protein that helps cancer cells divide and grow. Dabrafenib stops cells making the BRAF protein (a BRAF inhibitor). This can slow or stop the growth of cancer.
This treatment is only used in people with a change in the BRAF gene.
About 5 out of 10 people (about 50%) with melanoma have this change in the BRAF gene. Your doctor can take samples of the melanoma to see if this treatment is suitable for you.
How you have it
Dabrafenib is a tablet you take twice a day, 12 hours apart. The usual dose is 2 tablets.
You should take dabrafenib at least 2 hours after you have eaten. And after taking dabrafenib, you should wait at least 1 hour before you eat. You swallow the tablets whole with a glass of water. You shouldn't crush or chew them.
If you forget to take dabrafenib
Take it as soon as you remember if it is less than 6 hours late. If it is more than 6 hours, skip that dose and take the next dose at the usual time.
If you take more dabrafenib than you should
Taking your tablets or capsules
You should take the right dose, not more or less.
Talk to your specialist or advice line before you stop taking a cancer drug.
When you have it
You have dabrafenib alone or in combination with another cancer drug called trametinib.
Usually you continue taking dabrafenib for as long as it is helping you and the side effects aren't too bad.
You have blood tests before and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.
Your doctor checks your eyes regularly while you have this treatment. You also have your skin checked every month during treatment. And for 6 months after you stop dabrafenib.
You may have CT scans to check your head, neck and lymph glands. You may also have the skin around the back passage (anus) checked before and after treatment. And if you are a women, you might have genital examinations.
Other medicines, foods and drink
Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.
Pregnancy and contraception
This drug may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug and for at least a month afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.
Don’t breastfeed during this treatment because the drug may come through into your breast milk.
It is unknown whether this treatment affects fertility in people. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.
Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.
Don’t have immunisations with live vaccines while you’re having treatment and for up to 12 months afterwards. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations.
In the UK, live vaccines include rubella, mumps, measles, BCG, yellow fever and the shingles vaccine (Zostavax).
- have other vaccines, but they might not give you as much protection as usual
- have the flu vaccine (as an injection)
- be in contact with other people who have had live vaccines as injections
Avoid close contact with people who have recently had live vaccines taken by mouth (oral vaccines) such as oral polio or the typhoid vaccine.
This also includes the rotavirus vaccine given to babies. The virus is in the baby’s poo for up to 2 weeks and could make you ill. So avoid changing their nappies for 2 weeks after their vaccination if possible. Or wear disposable gloves and wash your hands well afterwards.
You should also avoid close contact with children who have had the flu vaccine nasal spray if your immune system is severely weakened.
More information about this treatment
We haven't listed all the very rare side effects of this treatment. For further information see the electronic Medicines Compendium (eMC) website.
You can report any side effect you have that isn’t listed here to the Medicines Health and Regulatory Authority (MHRA) as part of their Yellow Card Scheme.