A study of bone pain in people with myeloma (BPMM)

Please note - this trial is no longer recruiting patients. We hope to add results when they are available.

Cancer type:

Blood cancers





This study is looking at bone pain and what causes it in people with myeloma. It is open to people who are having tests to find out if they have myeloma. 

More about this trial

Myeloma is a type of blood cancer. It can cause bone pain that can affect how you walk and move around (your mobility). And this can affect your quality of life Open a glossary item

There has been little research into the causes of the bone pain. Researchers think it might be because of changes in the nerves of the bone. 

In this study researchers will look at blood samples and bone marrow Open a glossary item samples. They want to find substances (biomarkers Open a glossary item) that might tell them more about the cause of the bone pain. 

You fill in a quality of life questionnaire. This will tell the team how the pain is affecting your life. 

The main aims of this study are to understand:

  • more about bone pain in myeloma
  • what causes it
  • how it affects quality of life

Who can enter

The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if you at least 18 years old and are having tests to find out if you have myeloma.

Who can’t take part

You cannot join this study if any of these apply. You:

  • don’t speak English 
  • are not well enough 
  • have recently had chemotherapy for another type of cancer

Trial design

The study team expect 35 people to join this study. 

Before finding out you have myeloma
You fill in 8 questionnaires. The questions ask about:

  • pain that you have
  • what you can do
  • what symptoms you have
  • how you are feeling

This takes about 1 to 2 hours. You can do it at the hospital or take them home. There is a stamped addressed envelope supplied if you take them home. 

Research samples
You give 1 extra blood sample for the study. The team will ask for a small sample of your bone marrow when you have a bone marrow test. 

Follow up after finding out you have myeloma
8 months after your diagnosis the team invite you to fill in the questionnaires again. You also give another blood sample. 

You don’t have to agree to take part in this follow up. You can still take part in the main study. 

People who don’t have myeloma
The team want to collect information from people who don’t have myeloma so they can compare it with those who do. They will keep the information about people who aren’t diagnosed with myeloma.

But you won’t be followed up as part of the study.  

Hospital visits

The study team will try and take the samples at the same time you have your routine samples taken. 

The team give you the questionnaires at your routine hospital appointments.

Side effects

There are no side effects from taking part in this study.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Andrew Chantry

Supported by

Sheffield Teaching Hospitals NHS Foundation Trust
IMK Almene Fonden
University of Copenhagen

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Last reviewed:

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