A study looking at personalised treatment for early HER2 positive breast cancer (HER2-RADiCAL)

The following bullet points are a summary of the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this study if all of the following apply.

• You have invasive breast cancer that is HER2 positive .
• You had chemotherapy with trastuzumab and pertuzumab before surgery. 
• You had a scan before having chemotherapy that showed your cancer was 20mm or less in size. The scan showed cancer in 1 or more lymph nodes  in the lower or middle part of the armpit only. Or your cancer was between 21mm and 50mm in size and there is no cancer in any lymph nodes or there is cancer in 1 or more lymph nodes in the lower or middle part of the armpit. 
• Your surgery has removed all of the cancer. 
• A sample of tissue (biopsy ) taken before any treatment is available for the study team to access. 
• You must be able to continue with trastuzumab after surgery.
• You are willing to use reliable contraception during treatment and for a time after. This is if there is any chance you or your partner could become pregnant.
• You are at least 16 years old.

Who can’t take part

You cannot join this study if any of these apply.

• You have had invasive breast cancer before.
• You have had surgery to remove the area of cancer in the breast (breast conserving surgery). And you are not planned to have radiotherapy to the breast for example you don't want radiotherapy.
• There are signs that your cancer may have spread to another part of the body since your diagnosis. 
• There is still some cancer left at surgery after having your chemotherapy. 
• You plan to have more surgery to remove cancer for example surgery to remove the lymph nodes in the armpit. 
• At diagnosis your cancer was stage 3 or stage 4.
• Your sentinel lymph node  biopsy before having chemotherapy had cancer cells in it.
• There is scarring in 4 or more lymph nodes in the armpit. 
• You had more than 9 cycles of trastuzumab. 
• You had chemotherapy after surgery. 
• You have had another cancer in the last 5 years. This is apart from successfully treated non melanoma skin cancer  and abnormal cells on the surface of the cervix (CIN ). 
• You had a heart attack, unstable chest pain (angina) or any other major heart problem  within the year before starting trastuzumab. 
• You have in the past had inflammation of the lungs. 
• You are not able to have trastuzumab. 
• You are pregnant or breastfeeding.
• You have any other medical condition or mental health problem that could affect you taking part.