“Deborah agreed to take part in a trial as she was keen to help other cancer patients in the future. "If taking part in a trial means others might be helped then I’m very happy with that."
A study looking at a new type of mammogram to help diagnose breast cancer (CONTEND study)
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This study is comparing contrast enhanced spectral mammography (CESM) with magnetic resonance imaging (MRI) to see if it is better at finding breast cancer.
It is for women:
- with an abnormal area or breast
lesionthat needs to be looked at further
- going to the Cambridge Breast Unit
More about this trial
In this study, researchers are looking at a new type of mammogram called contrast enhanced spectral mammography (CESM).
CESM involves having an injection of a dye
Doctors think CESM can give a more accurate and detailed image of the breast than a normal mammogram. So it might reduce the need to have more tests to confirm a diagnosis of cancer.
In this study, women will have one of the following:
- standard care – this might include a physical examination, mammogram, ultrasound scan, MRI scan and
- CESM and standard care
The main aims of this study are to:
- find out if CESM can help diagnose breast cancer
- see if CESM is as good as an MRI scan at finding breast lesions
- see if CESM can reduce the number of
Who can enter
The following bullet points list the entry conditions for this study. Talk to your doctor or the study team if you are unsure about any of these. They will be able to advise you.
You may be able to join this study if you are a woman going to the Cambridge Breast Unit and all of the following apply
- You are aged 18 years or over
- You have an abnormal area or breast lesion and you need to have more tests
You cannot join this study if any of these apply
- You have breast
- You have had breast cancer
- Your kidneys don’t work very well
- You are known to be sensitive to the injection given during an MRI scan (contrast medium) or you have had a scan with contrast medium in the last 24 hours
- You have already started anti cancer treatment (such as surgery, chemotherapy or radiotherapy)
- You are pregnant
This is a pilot study. Researchers need about 100 women going to the Cambridge Breast Unit to take part.
This study is randomised. People taking part are put into 1 of the following groups by a computer:
- CESM and standard care
- Standard care
Neither you nor your doctor will be able to decide which group you are.
CESM and standard care
You will be asked to complete a questionnaire first. It will ask about your health and if you have had any problems with scans in the past.
After this you have the mammogram (CESM). A sample of cells (biopsy) will be taken if necessary.
After the CESM you might have other tests that would be part of standard care, such as an MRI scan. Your doctor will explain if any other tests are needed.
As part of standard care you might have:
- a physical examination
- another mammogram
- an ultrasound scan
- an MRI scan
- a biopsy
Your doctor will explain what tests you need.
If you have CESM and standard care, you might have 1 extra visit to the Cambridge Breast Unit. All other tests are part of your normal care.
The possible side effects of CESM are:
- pain at the contrast medium injection site
- sensitive reaction to contrast medium
- feeling or being sick
You also have an extra dose of
We have more information on having an MRI scan
How to join a clinical trial
Professor Fiona J Gilbert
Cambridge University Hospitals NHS Foundation Trust
NIHR Clinical Research Network: Cancer
University of Cambridge