"Health wise I am feeling great. I am a big supporter of trials - it allows new treatments and drugs to be brought in.”
A study following a group of men who have prostate cancer and gene changes (GENPROS)
Coronavirus and cancer
We know it’s a worrying time for people with cancer, we have information to help. If you have symptoms of cancer contact your doctor.
This study is looking at whether there are differences in how well prostate cancer treatment works if you have certain gene changes.
We know from research that men who have changes (mutations) to certain genes such as the BRCA1 and BRCA2 gene have an increased risk of developing prostate cancer. And if you are diagnosed with prostate cancer it may be more likely to grow and spread if you have one of these gene changes.
Cancer Research UK supports this trial.
More about this trial
- the BRCA 1 or BRCA 2 gene
- the HOXB13 gene
- the lynch syndrome genes
- the ATM gene
- other genes thought to be related to prostate cancer
Who can enter
- You have prostate cancer
- It is known whether or not you have certain changes (mutations) to genes – your doctor can tell you more about this
- You are at least 18 years old
- You have been diagnosed with prostate cancer while taking part in the IMPACT study
- It isn’t known whether or not you have certain gene changes
The researchers hope that around 3,660 men will join this study. If you agree to take part, you are giving the study team permission to look at your medical records. They will also ask for samples of your prostate cancer that are removed when you have a biopsy or surgery.
The study team will ask your doctors for an update on your treatment and how you are getting on every year. All the information collected about you is confidential.
The study team will ask you to give a sample of saliva or blood that they can use to study your DNA.
The researchers may look for inherited genes that could affect your risk of developing prostate cancer or how likely it is to grow and spread. There is a possibility that they may find information that could be relevant to you or your family’s medical care. If this happens, the study team may want to contact you. But when you agree to join the study, you can mark on the consent form if you do not want to be contacted with this information.
The study team may also speak with relatives of people who passed away due to prostate cancer and would be eligible for this research. They will ask their permission to look at tissue samples that were taken during surgery or biopsies. They also ask for permission to access their relatives’ prostate cancer medical records.
You may need to make an extra visit to hospital to discuss the study and give your saliva or blood sample.
Blood tests are very safe and the team doesn’t think you will have any side effects from taking part in this study.
Talking about your, or your loved one cancer can be upsetting. The research team will do all they can to make you feel comfortable. They can give you information about support if you need it.
How to join a clinical trial
Professor Ros Eeles
Cancer Research UK
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
Ronald and Rita McAulay Foundation
University of Cambridge