A trial of nivolumab and ipilimumab for small cell lung cancer that has spread (CA209451)

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

You may be able to join this trial if all of the following apply.

• You have small cell lung cancer that had spread to another part of your body when first diagnosed 
• Your cancer went away completely, a little bit or stayed the same after no more than 4 cycles of treatment with a platinum drug such as cisplatin or carboplatin and this was the first treatment you had. You may be able to take part if you only had 3 cycles of treatment but had to stop early due to side effects and your cancer stayed the same or got a bit better.
• Your last dose of chemotherapy was no more than 9 weeks before you join the trial
• The trial team can test a sample of tissue that was removed when you had your lung cancer surgery or biopsy or you are willing to have a sample of tissue taken
• You are well enough to carry out all your normal activities, apart from heavy physical work (performance status 0 or 1)
• You have satisfactory blood test results
• You are at least 18 years old
• You are willing to use reliable contraception during treatment and for 6 months afterwards if there is any chance you or your partner could become pregnant

You cannot join this trial if any of these apply. You

• Have cancer that has spread to the brain or spinal cord unless this has been successfully treated and you no longer take steroids
• Have cancer that has spread to the tissues surrounding your brain (carcinomatous meningitis) 
• Are having radiotherapy to your chest
• Have a fluid build up around your lung (pleural effusion ) and treatment isn’t working
• Have an autoimmune disease
• Have been taking steroids or other medication that dampen down your immune system (you can take part if you use steroid creams, inhalers or eye drops) 
• Have a condition called interstial lung disease 
• Have already had a drug that targets PD-1, PD-L1, PD-L2, CD137 or CTLA-4
• Have already had ipilimumab or another drug that works in a similar way
• Have side effects from past treatments apart from hair loss or nerve damage (peripheral neuropathy)  and they are mild
• Have had any other cancer in the past apart from very early cancers that have been successfully treated more than 2 years ago
• Have had major surgery or a very bad injury that isn’t getting better in the last 2 weeks 
• Are allergic or sensitive to any of the drugs used in this trial
• Have any other medical condition or mental health problem that the trial team think would affect you taking part in this trial
• Are known to have HIV, hepatitis B or hepatitis C
• Are pregnant or breast feeding