Header image for Determine which is a rare cancer clinical trial, you can see doctors testing cancer therapies and a mother of a child suffering of cancer.

DETERMINE is a cutting edge UK national precision medicine trial in rare cancers, testing a range of therapies specifically targeting key genetic changes in cancer cells.

Patient's referral

1. Patient referral

Contact a local investigator at an actively recruiting DETERMINE site to discuss your patient and initiate a referral.

2. Formal submission

After seeking consent from the patient to share their data, the local investigator will make a formal submission to the DETERMINE Molecular Tumour Board (MTB).

You'll need to provide any relevant clinical and genomic data.

3. Decision

The MTB will aim to return their decision to the local investigator within 5 working days.

The patient will need to sign an informed consent document for the specific treatment arm in the trial.

Participating sites

Participant site

Investigator contact

Adult/Paediatric site

Status

The Royal Marsden Hospital NHS Foundation Trust, Surrey Dr Lynley Marshall Paediatric RECRUITING
University Hospital Birmingham NHS Foundation Trust, Birmingham Professor Gary Middleton Adults RECRUITING
The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne Professor Alastair Greystoke Adults / Paediatric RECRUITING
The Christie NHS Foundation Trust, Manchester Dr Matthew Krebs Adults RECRUITING
Oxford University Hospitals NHS Foundation Trust, Oxford Dr Sarah Pratap Adults / Paediatric RECRUITING
Cambridge University Hospitals NHS Foundation Trust, Cambridge Dr Bristi Basu Adults / Paediatric RECRUITING
University Hospitals of Leicester NHS Trust, Leicester Dr Olubukola Ayodele Adults RECRUITING
The Guy's and St Thomas' NHS Foundation Trust, London Professor James Spicer Adults RECRUITING
Alder Hey children NHS Foundation Trust , Liverpool Dr Lisa Howell Paediatric RECRUITING
Weston Park Hospital, Sheffield Professor Sarah Danson Adults RECRUITING
Great Ormond Street Hospital, London Professor Darren Hargrave Paediatric RECRUITING
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol Dr Antony Ng Adults / Paediatric RECRUITING
University College London Hospitals NHS Foundation Trust, London Professor Martin Forster Adults RECRUITING
Birmingham Women’s and Children’s NHS Foundation Trust, Birmingham Dr Susanne Gatz Paediatric In set up
University Hospital Southampton NHS Foundation Trust, Southampton Prof Juliet Gray Adults / Paediatric In set up

Participant site

Investigator contact

Adult/Paediatric

Status

Belfast Health and Social Care Trust, Belfast                                                             Professor Vicky Coyle                Adults RECRUITING

 

Participant site

Investigator contact

Adult/Paediatric

Status

Beatson West of Scotland Cancer Centre (NHS Greater Glasgow & Clyde), Glasgow Dr Patricia Roxburgh Adults RECRUITING
Western General Hospital (NHS Lothian), Edinburgh Dr Stefan Symeonides  Adults RECRUITING
Royal Hospital For Children Glasgow (NHS Greater Glasgow & Clyde), Glasgow Dr Milind Ronghe Paediatric RECRUITING

 

Participant site

Investigator contact

Adult/Paediatric

Status

Velindre University NHS Trust, Cardiff                                                                           Professor Robert Jones Adults RECRUITING