"I am glad that taking part in a trial might help others on their own cancer journey.”
A trial of interleukin-2 with or without histamine dihydrochloride in advanced kidney cancer
When this trial started at the end of 1990s doctors thought that another drug, histamine dihydrochloride (HDC), may help IL-2 to work better. In this trial, some people had IL-2 alone, and some had IL-2 and histamine dihydrochloride.
The aim of this trial was to find out if IL-2 and histamine dihydrochloride was better for advanced kidney cancer that IL-2 alone.
Summary of results
This trial showed that there was no benefit in giving histamine dihydrochloride (HDC) as well as interleukin 2 (IL-2) for advanced renal cell cancer.
This trial recruited 41 people,
- 20 had interleukin 2 alone
- 21 had interleukin 2 and histamine dihydrochloride
The research team looked at
- How well renal cell cancer responded to treatment
- How many people had signs that their cancer had continued to grow
- The number of people alive a year after treatment.
They found that there was no difference between the 2 groups in any of these.
They found that the side effects were generally mild or moderate, although a small number of people had more severe side effects.
A trial done in Denmark around the same time showed slightly more promising results. So the research team concluded that more work should be done to help decide if histamine dihydrochloride was useful or not.
We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Prof Mark Middleton
The Christie NHS Foundation Trust