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A study looking at measuring a substance called citrate to diagnose prostate cancer
This study looked at measuring the level of citrate in semen to detect cancer.
If your doctor thinks you may have prostate cancer you will have some tests. These include a prostate biopsy and blood test called a PSA test.
More about this trial
Researchers wanted to look at a possible new test for prostate cancer. They measured levels of a substance called citrate in
The aim of this study was to see if measuring citrate levels in semen could be useful as a test to diagnose prostate cancer.
Summary of results
The research team found that citrate levels in semen could be a useful indicator of prostate cancer.
This trial recruited men who were having tests for prostate cancer. The research team looked at 32 samples. For each person taking part they looked at
- The level of citrate
- PSA level
- Biopsy results - and the grade of cancer if they had prostate cancer
- The Gleason score
They found that
- The 3 men taking part who had high grade prostate cancer also had the lowest level of citrate
- There was no link between the level of citrate and the PSA level
- For the 7 men who had an operation to remove their prostate (a radical prostatectomy), there was a link between the grade of cancer and citrate level
The research team are keeping an eye on 2 men who didn’t have prostate cancer but had a raised PSA level and a low citrate level. They think the low citrate level may mean these men have very early stage prostate cancer, and they would like to find out more.
They concluded that measuring citrate level in semen could be useful to help diagnose prostate cancer.
We have based this summary on information from the team who ran the trial. As far as we are aware, the information they sent us has not been reviewed independently (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Professor David Parker
James Cook University Hospital
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040