A trial looking at pertuzumab for breast cancer that has spread (BO16934)

Cancer type:

Breast cancer




Phase 2

This trial looked at pertuzumab (also called Omnitarg) for breast cancer that had spread.

Doctors can use surgery, radiotherapy, chemotherapy and hormone therapy to treat breast cancer. But sometimes the cancer continues to grow or comes back after treatment. If the cancer spreads outside the breast or comes back in another part of the body, it is called metastatic breast cancer.

Pertuzumab is a monoclonal antibody. Monoclonal antibodies are a type of biological therapy. They look for specific proteins on the surface of cells. Pertuzumab looks for a protein called HER2, which is made by some breast cancers. If HER2 is made by the cancer cells, the cancer is called ‘HER2 positive’.

The amount of HER2 protein made varies between different breast cancers. Doctors hoped that pertuzumab would be useful for treating metastatic breast cancers with a low or medium level of HER2.

The aims of the trial were to

  • See how well pertuzumab worked
  • Compare two different doses
  • Learn more about the side effects

Summary of results

The researchers found that pertuzumab did not help women with metastatic breast cancer as much as they had hoped.

The trial recruited 78 women all together. 41 had a low dose of pertuzumab once every 3 weeks.

  • In 2 women, the cancer got smaller – doctors call this a partial response Open a glossary item, but this response only lasted in one woman
  • In 18 women, the cancer remained the same – researchers call this stable disease Open a glossary item
  • In 21 the cancer got bigger

37 women had a higher dose of pertuzumab

  • In 14 women there was stable disease
  • In 22 women the cancer got bigger
  • The researchers didn’t have results for 1 woman

In 6 women, a partial response or stable disease had lasted for more than 6 months. The number of responses was about the same for both doses.

5 women had side effects during the injection of pertuzumab, including dizziness, rash, chills, fever and shortness of breath. Other side effects included diarrhoea, sickness and weakness.

We have based this summary on information from the team who ran the trial. As far as we are aware, the information they sent us has not been reviewed independently (peer reviewed Open a glossary item) or published in a medical journal yet. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr David Cameron
Dr Andrew Wardley
Dr David Miles

Supported by


If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:

Oracle 291

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Deborah wanted to help other breast cancer patients in the future

A picture of Deborah

“Deborah agreed to take part in a trial as she was keen to help other cancer patients in the future. "If taking part in a trial means others might be helped then I’m very happy with that."

Last reviewed:

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