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A trial to find out if more people with bowel cancer could have cetuximab and panitumumab (ARIEL)

Overview

Cancer types:

Bowel (colorectal) cancer, Colon cancer, Secondary cancers

Status:

Open

Phase:

Phase 4

Details

This trial is looking at to see if cetuximab and panitumumab could help more people.

It is for people who have bowel cancer:

  • that started on the right side of the bowel

  • that has spread. This is advanced or metastatic cancer.

  • with a normal RAS gene in the bowel cancer cells

Depending on the levels of biomarkers, you may have treatment as part of this trial.

Recruitment start: 25 April 2022

Recruitment end: 30 September 2026

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Dr Jenny Seligmann Professor Richard Adams

Supported by

University of Leeds

National Institute for Health Research (NIHR) Efficacy and Mechanism Evaluation (EME) Programme

Last reviewed: 02 Sept 2025

CRUK internal database number: 18059

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