Please note
This trial is no longer recruiting patients. We hope to add results when they are available.
Children's cancers
Closed
Phase 1/2
This trial is looking at a drug called plerixafor which can help to move stem cells from your bone marrow into your bloodstream. This is called stem cell mobilisation.
Plerixafor has already been tested and approved for use in adults with and . The current trial is for children and young people with a who are going to have having a stem cell transplant using their own cells (an ).
The trial is for children and young people from 1 year old up to the age of 18. We use the term ‘you’ in this summary, but of course if you are a parent, we are referring to your child.
When you have an autologous stem cell transplant, stem cells are collected from your blood using a . After having treatment to kill the cancer cells, you have the collected stem cells back through a drip. They find their way into the bone marrow and start to make blood cells again to replace the cells which were damaged or destroyed by the treatment to kill the cancer cells.
Before your stem cell collection, you have drugs to help the bone marrow make more stem cells and move them into your bloodstream. You may have and a growth factor called G-CSF. Or you may have G-CSF alone. These are both plans.
In this trial, researchers are looking at adding a drug called plerixafor to standard treatment. Plerixafor blocks a protein on the surface of stem cells that ‘ties’ them to the bone marrow. We know from research that plerixafor can help move stem cells from the bone marrow into the bloodstream in adults. Researchers want to see if it can help in children and young people.
The aims of this trial are to
Find the best safe dose of plerixafor that children can have
Learn more about what happens to plerixafor in your body
See if adding plerixafor to standard treatment helps children having a stem cell transplant using their own cells
Recruitment start: 15 January 2011
Recruitment end: 30 November 2014
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr B. Morland
Experimental Cancer Medicine Centre (ECMC)
Genzyme
a Sanofi Company
Last reviewed: 22 December 2014
CRUK internal database number: 8061
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