A trial of TDM1 with or without pertuzumab for breast cancer that has spread (MARIANNE)

Overview

Cancer types:

Breast cancer, Secondary cancers

Status:

Results

Phase:

Phase 3

Details

This trial looked at trastuzumab emtansine (TDM1) and pertuzumab for breast cancer that had come back or spread to another part of the body. It was for people who had breast cancer that was .

The trial was open for people to join between 2010 and 2012. The team reported results in 2017 and 2019.

There is a link to more information in the ‘Summary of results’ section below.

Recruitment start: 6 July 2010

Recruitment end: 2 May 2012

How to join

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Chief investigators

Professor Coleman

Supported by

Experimental Cancer Medicine Centre (ECMC)

Genentech Ltd

NIHR Clinical Research Network: Cancer

Hoffmann-La Roche

Last reviewed: 23 Oct 2026

CRUK internal database number: 6817

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