
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a drug called pomalidomide with a low dose of the steroid dexamethasone for myeloma that is not responding to treatment or has come back. The people taking part have myeloma and their kidneys are not working very well.
The main treatments for myeloma include chemotherapy, steroids such as dexamethasone, and biological therapies such as bortezomib and lenalidomide. If these 2 drugs don’t help, or stop working, doctors can use another drug called pomalidomide alongside a low dose of dexamethasone.
Pomalidomide affects how your immune system works. It is a type of drug called an immunomodulatory agent.
Many people with myeloma have some damage to their . Doctors call this renal impairment. People taking part in this trial have either moderate or severe renal impairment.
The main aim of the trial is to see how well pomalidomide and low dose dexamethasone works for people who have myeloma and renal impairment.
You may be able to join this trial if all of the following apply. You
You cannot join this trial if any of these apply. You
This is a phase 2 trial. The researchers need 80 people to join. Everybody taking part has pomalidomide and low dose dexamethasone.
You have treatment in 4 week periods called cycles of treatment. You take
As long as you don’t have bad side effects, you can carry on having the treatment for as long as it helps you.
You see the trial team and have some tests before you start treatment. The tests include
You may also need to have a of your kidney.
You go to hospital once a week for the first 8 weeks of treatment. After that, you go once every 4 weeks. You have regular blood tests and urine tests. You have a heart trace every 3 months.
You may need to have another bone marrow test. And you may need to have more X-rays, MRI scans or CT scans.
When you finish treatment, you see the trial team again about 4 weeks later and have a physical examination, blood tests and urine tests. After that, they will check how you are every 3 months for up to 5 years. This can either be at routine hospital visits or by phone calls.
The most common side effects of pomalidomide include
We have more information about
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr M Streetly
Celgene Corporation
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”