“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A trial of olaparib for advanced prostate cancer that has got worse after standard treatment (TOPARP)
This trial looked at olaparib for men with prostate cancer that had spread elsewhere in the body. The men taking part had cancer that got worse despite hormone therapy and chemotherapy drugs called
Cancer Research UK supported this trial.
The trial was open for people to join between 2012 and 2018. The team published results of the first part of the trial (TOPARP A) in 2015 and further results of the second part of the trial (TOPARP B) in 2020.
More about this trial
Doctors can treat advanced prostate cancer with chemotherapy and hormone therapy. But sometimes these treatments stop working. So doctors are looking for treatments to help people in this situation. In this trial they looked at a drug called olaparib.
Olaparib is a
Olaparib is already a treatment for people with ovarian or breast cancer.
The aims of this trial were to find out if:
- olaparib worked for men with prostate cancer whose treatment had stopped working
- some men are more likely to benefit from olaparib than others
Summary of results
The researchers found that olaparib worked for men with advanced prostate cancer. It worked best for men who had certain gene changes (
About this trial
This was a phase 2 trial.
There were 2 parts to this trial:
- TOPARP A
- TOPARP B
In this part, everyone had 400mg of olaparib twice a day. The research team looked at tumour samples (
Men were put into 1 of 2 groups at random. They had 1 of the following:
- 300mg olaparib twice a day
- 400mg olaparib twice a day
This part of the trial was only for men who had changes in genes that helped repair DNA. The trial team looked at tumour samples to identify these genes. Some of the genes they were looking for included the
Everyone had treatment for as long as it was working and the side effects weren’t too bad.
The men had regular blood tests and scans every 3 months. The researchers followed everyone up for an average of about 25 months. They looked at the results to see how well treatment worked.
The researchers said that treatment worked if any of the following applied:
- a decrease in the
PSA levelby half (50%) compared to the level before starting treatment
- a scan that showed the tumour had shrunk by a certain amount
- a drop in the number of circulating tumour cells in the blood – these are tumour cells that have broken away from the prostate and are circulating in the blood
These results had to be confirmed again at least 4 weeks later with another blood test or scan.
The trial team analysed the results for both parts of the trial. Their findings are summarised below.
49 men joined this part of the trial. Researchers looked at how well treatment worked. They looked at tumour samples.
They found that 16 men had tumours with changes in the DNA repair genes.
The researchers found that, in 14 of these men, olaparib prevented cancer growth for 10 months on average.
In the 33 men with tumours that did not have changes in DNA repair genes, olaparib worked for only 2 and prevented cancer growth for 3 months on average.
So the researchers concluded that treatment worked better in men whose tumours had faults in genes involved in repairing DNA.
This part of the trial was for men with cancers that had gene changes in the DNA repair genes. Researchers tested tumour samples to check for this.
161 men had tumours with changes in 1 or more of these genes. Of those 98 were put into a group at random and had treatment.
- 49 had 300 mg olaparib
- 49 had 400 mg olaparib
They had the results for 46 men in each group. So 92 men in total. The researchers found that treatment worked for:
- 25 out of 46 men who had 400mg of olaparib
- 18 out of 46 men who had 300mg of olaparib
They found that olaparib stopped the cancer starting to grow again by an average of 5.5 months. They looked at how long men lived on average. This was about:
- 14 months in men who had 400mg olaparib
- 10 months in men who had 300mg of olaparib
A few more men who had the higher dose of olaparib had side effects. The most common serious side effects of olaparib were:
- a drop in the number of red blood cells (
- tiredness (fatigue)
The trial team found that olaparib worked well for men with advanced prostate cancer who had specific changes in their cancer cells. It worked for men with:
- inherited gene faults such as BRCA1 and BRCA2
- gene changes within the cancer cells that weren’t inherited
The trial team concluded that these results support testing tumour samples for changes in the DNA repair genes. They say by testing for the gene changes before starting treatment it is possible to select men with a high chance of olaparib working.
Results from TOPARP A led to a larger trial called PROFOUND (now closed to recruitment). The trial team are continuing to look at the data collected in TOPARP B to understand more about how olaparib works.
Where this information comes from
We have based this summary on information from the research team. The information they sent us has been reviewed by independent specialists (
How to join a clinical trial
Professor Johann de Bono
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
Institute of Cancer Research (ICR)
NIHR Clinical Research Network: Cancer
The Royal Marsden NHS Foundation Trust
Prostate Cancer UK
The Prostate Cancer Foundation
This is Cancer Research UK trial number CRUK/11/029