
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a type of to help delay or stop non small cell lung cancer coming back after surgery. If it’s diagnosed early enough, doctors may treat non small cell lung cancer (NSCLC) with surgery. You may also have chemotherapy after your surgery.But there is a risk that your cancer could come back and researchers are looking for new treatments to try to stop this happening.
In this trial, they are testing a treatment called PRAME immunotherapy. It works by teaching your immune system to recognise and destroy cancer cells.
You have injections of an that is found in your tumour (the PRAME antigen). To help your immune system, another substance called an adjuvant is added to the antigen. The adjuvant is a mixture of natural and manmade substances that help the immune system to respond.
The aims of the trial are to
You may be able to enter this trial if you
You cannot enter this trial if you
This phase 2 trial aims to recruit 220 people in a number of different countries. It is a randomised trial. The people taking part are put into treatment groups by a computer. Neither you nor your doctor will be able to decide which group you are in. And neither of you will know which group you are in. This is called a double blind trial.
To begin with, the researchers need your permission to test your cancer to see if it produces the PRAME antigen. A piece of your cancer removed during surgery will be sent to the laboratory. It takes about a week to do this test. If your lung cancer does make the antigen, the trial team will give you more information about the trial and ask if you want to join.
If you agree to take part in the trial, you have up to 13 injections into a muscle in your thigh or your arm over the course of the treatment. Some people have PRAME immunotherapy, some have dummy injections (). There are twice as many people in the immunotherapy group as in the group having dummy injections.
You start having the trial injections after your surgery. If you have chemotherapy after surgery, you start the injections after your chemotherapy.
For the first 5 treatments, you have an injection once every 3 weeks. For the next 8 treatments, you have an injection once every 3 months.
You have regular blood tests throughout the trial. The researchers will look at your blood samples to see how your immune system is responding to the treatment.
The trial team will ask to take one extra blood sample to look at how differences in people’s DNA could be linked to the response to PRAME immunotherapy. But this test is optional. If you don’t want to give this sample for research you don’t have to. You can still take part in the trial.
If your cancer comes back during treatment, you will stop the injections and the trial doctor will talk to you about other treatment options. The trial team will then phone you once a year for up to 5 years to see how you are.
You see the trial team and have some tests before you start the injections. The tests include
You go to hospital to have the injections every 3 weeks for the first 12 weeks and then every 3 months for nearly 2 years. You have blood tests before each injection.
You have more CT scans during the trial to check if your cancer has come back. You have them every 3 months for 6 months, then every 6 months until a year after you have finished treatment, then once a year.
You see the trial team again 4 weeks after your last injection. You have follow up appointments after 2 months and then every 6 months for up to 5 years.
As PRAME immunotherapy is a new treatment, there may be side effects we don’t know about yet. The possible side effects include
Rarely, people have a severe reaction to immunotherapy. If this happens, it can be treated and you will not have any more injections.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Paul Taylor
GlaxoSmithKline (GSK)
NIHR Clinical Research Network: Cancer
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”