A trial of GC4711 and SBRT for pancreatic cancer (GRECO-2)

The following bullet points are a summary of the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you. 

Who can take part

You may be able to join this trial if all of the following apply. You:

• have adenocarcinoma  of the pancreas
• have newly diagnosed pancreatic cancer that hasn’t spread to other parts of the body
• have cancer that has grown into surrounding tissues and it isn’t possible to remove, it could be difficult to remove or you don’t want to have surgery
• have a CT scan  to confirm your cancer hasn’t spread elsewhere in the body after your chemotherapy is finished
• are suitable to have stereotactic body radiotherapy (SBRT)
• have cancer that your doctor can see on a scan 
• have completed at least 6 weeks of a combination of chemotherapy called FOLFIRINOX, modified FOLFIRINOX or a combination of chemotherapy that included gemcitabine before starting SBRT
• have satisfactory blood test results 
• are up and about more than half the day, you can look after yourself but might not be able to work (performance status 0 to 2)
• are willing to use reliable contraception during treatment and for a period of time after if there is any chance you or your partner could become pregnant. 
• are at least 18 years old 

Who can’t take part

Cancer related
You cannot join this trial if any of these apply. You:

• have cancer that has spread elsewhere in the body
• have had chemotherapy other than FOLFIRINOX, modified FOLFIRINOX or a combination of chemotherapy that included gemcitabine before starting SBRT
• have pancreatic cancer that has grown into the bowel or stomach 
• have already had radiotherapy to the tummy (abdomen) that overlaps where you will have your SBRT
• have side effects from past treatments that aren’t better
• have another cancer that needs treatment 
• are having treatment with an experimental drug as part of another clinical trial

Medical conditions
You cannot join this trial if any of these apply. You:

• have a significant heart problem  or heart condition that isn’t well controlled with medication. Your doctor checks your heart before you join the trial.
• have a peptic ulcer  that isn’t well controlled with treatment within 30 days of starting trial treatment 
• have an ongoing infection that would delay your treatment 
• have a condition called Gilbert’s syndrome
• have a low level of potassium in the blood with a change to your heart rhythm  
• are having treatment with another drug that can cause a drop in your blood pressure. Your doctor will check the medications you are taking. 
• have any other health condition or mental health problem that the trial team think would affect you taking part

Other 
You cannot join this trial if any of these apply. You:

• have had an allergic reaction to another drug similar to GC4711 or anything it contains 
• are pregnant or breastfeeding