A trial of everolimus and BEZ235 for advanced solid tumours

This trial is looking at 2 drugs called everolimus and BEZ235 for advanced including breast cancer and kidney cancer. It is for people who have cancer that has spread to other parts of the body. A solid tumour is any type of cancer apart from or .

Everolimus is a type of biological therapy called an mTOR inhibitor. It stops a protein called mTOR from working properly. BEZ235 is a new drug that blocks the activity of mTOR and another protein called PI3K.

Both mTOR and PI3K are involved in cell growth. Blocking these 2 proteins may help stop cancer cells growing.

The aims of this trial are to

• Find the highest doses of everolimus and BEZ235 that you can safely have together

• Learn more about the side effects and what happens to the drugs in your body

• See how these 2 drugs affect breast cancer and kidney cancer