"I am glad that taking part in a trial might help others on their own cancer journey.”
A trial of a drug called tefinostat for liver cancer
This trial looked at tefinostat for the most common type of liver cancer called hepatocellular carcinoma (HCC).
This trial was open for people to join between 2012 and 2017. The team reported the results in 2019.
Cancer Research UK supported this trial.
More about this trial
There are a number of different treatments for cancer that starts in the liver. But sometimes they stop working and the cancer gets worse. Researchers are trying to improve treatment for people with hepatocellular carcinoma. In this trial they looked at a drug called tefinostat.
Researchers thought that tefinostat could help people with liver cancer. This was the first time people with liver cancer had tefinostat.
The aims of the trial were to:
- find the best dose of tefinostat for people with hepatocellular carcinoma (HCC)
- see how well it works
- learn more about the side effects
Summary of results
The team found the best dose of tefinostat to give to people with hepatocellular carcinoma (HCC).
The study took place in the UK. It was a phase 1/2 trial. There were 2 parts to the trial. Part 1 was to find the best dose. Part 2 was to test this dose in more people.
17 people joined part 1. They took tefinostat once or twice a day.
The first people taking part had a low dose of tefinostat. The next few people had a higher dose if they didn’t have any side effects. And so on, until the researchers found the best dose to give. This is called a dose escalation study.
Everyone had treatment for as long as it was working and the side effects weren’t too bad.
Once the team had found the best dose in part 1, they hoped to test it in more people.
The trial team found 2 doses of tefinostat to give. They recommended the higher dose for part 2 of the trial.
Part 2 didn’t go ahead as planned. This was because there had been changes in how trials were set up and designed since this trial first began. For example, trials were run differently and there were newer treatments. The team say they would have had to redesign this trial which would take a long time. So they decided to close the trial earlier than planned.
Everyone had at least 1 side effect.
Some of the more common side effects of tefinostat were:
- changes to how the liver and kidneys work
- shortness of breath
- diarrhoea or constipation
- tummy pain
- feeling or being sick
- muscle or joint pain
- loss of appetite
The trial team found the best dose of tefinostat to have. The trial closed earlier than planned so they didn’t test this dose in more people.
Even so, all trial results help doctors and researchers understand more about different cancers and the best way to treat them.
Where this information comes from
We have based this summary on information from the research team. As far as we are aware, the information they sent us has not been reviewed independently (
How to join a clinical trial
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr David Propper
Cancer Research UK
Experimental Cancer Medicine Centre (ECMC)
NIHR Clinical Research Network: Cancer
Queen Mary University of London
This is Cancer Research UK trial number CRUKD/12/011.