“I think it’s really important that people keep signing up to these type of trials to push research forward.”
A trial of cetuximab with or without irinotecan for advanced bowel cancer (ICE CREAM)
This trial looked at cetuximab on its own or with irinotecan for bowel cancer that had spread to another part of the body (advanced bowel cancer).
More about this trial
The research team looked at how well these treatments worked for people with and without changes (mutations) in specific genes. They think that changes in genes may affect how well treatments work.
In this trial some people had cetuximab alone, some had it with irinotecan.
Summary of results
- 21 had cetuximab
- 25 had cetuximab and irinotecan
- got smaller in 1 out of 10 people (10%) who had cetuximab alone
- got smaller or went away completely in just under 4 out of 10 people (38%) who had cetuximab and irinotecan
- more than 1 out of 10 people (14%) who had cetuximab alone
- just over 4 out of 10 people (41%) who had cetuximab and irinotecan
- more than 2 out of 10 people (23%) who had cetuximab alone
- 5 out of 10 (50%) who had cetuximab and irinotecan
How to join a clinical trial
Dr Harpreet Wasan
Australasian GastroIntestinal Trials Group (AGITG)
Experimental Cancer Medicine Centre (ECMC)
Imperial College Healthcare NHS Trust
NIHR Clinical Research Network: Cancer