
"I am glad that taking part in a trial might help others on their own cancer journey.”
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is comparing two treatments for non small cell lung cancer. The first treatment is atezolizumab and tiragolumab. The other treatment is durvalumab.
It is for people with non small cell lung cancer that:
Chemoradiotherapy is a combination of chemotherapy and radiotherapy. After chemoradiotherapy you might have durvalumab to strengthen the effect of the chemoradiotherapy.
Durvalumab is an . It works by stimulating the
to fight cancer. This can slow down or stop the growth of the cancer.
Atezolizumab and tiragolumab are also immunotherapies.
In this trial researchers want to compare durvalumab with atezolizumab and tiragolumab. Half the people taking part will have durvalumab and the other half will have atezolizumab and tiragolumab.
The aims are to find out:
The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.
Who can take part
You may be able to join this trial if all of the following apply. You:
Who can’t take part
Cancer related
You cannot join this trial if any of these apply. You:
Medical conditions
You cannot join this trial if any of these apply. You:
Other
You cannot join this trial if any of these apply. You:
This is an international phase 3 trial. The team need 800 people worldwide to join with 32 people from the UK.
It is a randomised trial. There are 2 groups. Neither you nor your doctor can choose which group you are in. The groups are:
You have durvalumab as a drip into a vein. You have it every 2 or 4 weeks.
You have atezolizumab and tiragolumab as a drip into a vein. You have them every 4 weeks.
You have treatment for a year as long as it is working and the side effects aren’t too bad.
Questionnaires
You fill in questionnaires:
If you stop treatment early and your cancer hasn’t got worse you fill in the questionnaires at every clinic visit. You do this until your cancer gets worse.
The questions ask about:
These are quality of life questionnaires.
Research samples
You give blood samples before you start treatment and several times during the trial.
The trial team will ask for a sample of tissue () when your cancer gets or when it improves as along as it is safe to do so. You don’t have to agree to have this biopsy taken. You can still take part in the trial.
They will use these samples to:
You see the doctor to have tests before taking part. These tests include:
You see the doctor before each treatment to see how you are and for bloods.
You have a scan every:
You see the doctor within a month of finishing treatment. Your doctor will then tell you how often they want to see you.
The trial team monitor you during treatment and afterwards. Contact your advice line or tell your doctor or nurse if any side effects are bad or not getting better.
Durvalumab, atezolizumab and tiragolumab can affect the immune system. They may cause inflammation in different parts of the body. This can cause serious side effects. These side effects could happen during treatment, or some months after treatment has finished. Rarely, they can be life threatening. Tell your doctor or nurse as soon as possible if you have any of these side effects. And tell them that you are having or have had an immunotherapy. |
Tiragolumab has not been used much in people. So there may be side effects we don’t know about. The side effects of tiragolumab we do know about are:
The most common side effects of atezolizumab are:
We have more information about atezolizumab and information about durvalumab and its side effects.
Your doctor or a member of the trial team will talk to you about the treatment you are having and possible side effects before you agree to take part.
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Jonathan Hicks
Roche
If you have questions about the trial please contact our cancer information nurses
Freephone 0808 800 4040
"I am glad that taking part in a trial might help others on their own cancer journey.”