A trial of 2 treatments for advanced neuroendrocrine tumours of the pancreas (SEQTOR)

The following bullet points list the entry conditions for this trial. Talk to your doctor or the trial team if you are unsure about any of these. They will be able to advise you.

Who can take part

You may be able to join this trial if all of the following apply.  
You:

• have a neuroendocrine tumour of the pancreas that can’t be removed with an operation and has spread elsewhere in the body
• have low grade NET of the pancreas (grade 1 or grade 2)
• have a sample of tissue (biopsy ) available for the trial team to do some tests on
• have cancer that the doctor can see and measure on a scan
• have satisfactory blood test results
• have cancer that got worse in the 12 months before joining the trial 
• are well enough to be up and about for at least half the day (performance status 0, 1 or 2)
• are willing to use reliable contraception for up to 30 days after treatment if there is any chance you or your partner could become pregnant
• are at least 18 years old
   

Who can’t take part

You cannot join this trial if any of these apply. 

Cancer related
You:

• have cancer cells that look very abnormal under a microscope and are growing quickly (grade 3 cancer) 
• have had chemotherapy and or certain targeted drugs  such as sirolimus, everolimus, sunitinib, sorafenib or axitinib in the past
• have had immunotherapy  or radiotherapy in the 4 weeks before joining the trial
• have had a substance such as a gel or tiny beads to block the blood supply to the NET spread to the liver (hepatic artery embolization) in the last 6 months or radiofrequency ablation  in the last 2 months
• have had a type of internal radiotherapy called peptide receptor radionuclide therapy (PPRT) in the last 6 months or you had this treatment and your NET hasn’t got worse
• have another cancer apart from basal cell skin cancer , squamous cell skin cancer , a very early cancer (carcinoma insitu ) or any other cancer that has been successfully treated and there haven’t been any signs of it for 3 years
• are taking part in another clinical trial using an experimental drug 

Medical conditions
You:

• have angina that isn’t well controlled with medication, congestive heart failure, a heart attack in the last 6 months or an abnormal heart rhythm that isn’t well controlled with medication
• have an active infection or an infection that isn’t getting better with treatment
• have severe liver damage
• have a severe lung problem
• have an increased risk of bleeding
• have diabetes that isn’t well controlled with medication
• are taking long term steroids or any other treatment that damps down the immune system
• have HIV 

Other
You: 

• are having treatment or herbal supplements that affect the CYP enzymes
• are allergic to everolimus, 5FU or streptozotocin or anything they contain
• have a low or no levels of an enzyme called DPD in your body (DPD deficiency)
• are pregnant or breastfeeding