A trial looking at vemurafenib after surgery for melanoma (BRIM 8)

This trial is looking at the use of vemurafenib for people who have had surgery to remove melanoma skin cancer.

Doctors often treat melanoma with surgery. Even when the cancer has been completely removed, it can sometimes come back (recur). Doctors are looking for new treatments that can reduce the risk of this happening.

Vemurafenib is a type of biological therapy called a cancer growth blocker. It stops cells producing a protein called BRAF, which makes some cancer cells grow and divide.

Vemurafenib is already used to treat some people with advanced melanoma. Doctors want to know whether this drug would help people with earlier stage melanoma who have a high risk of their cancer coming back.

The aims of the trial are to

• Find out if vemurafenib can reduce the risk of melanoma coming back, or delay it

• Learn more about how vemurafenib works in the body

• Learn more about the side effects