A trial looking at two different types of endoscope

Cancer type:

Bowel (colorectal) cancer





This trial was for people who were taking part in the Bowel Cancer Screening Programme (BCSP) and were offered a colonoscopy.

As part of the bowel cancer screening programme you are offered a test called a colonoscopy. For this a flexible tube with a camera on the end (endoscope) is used to look at the inside of your bowel.

More about this trial

Doctors look for and remove small growths called polyps that might develop into cancer in the future. So removing bowel polyps reduces your risk of bowel cancer.
In this trial researchers compared 2 makes of a camera (endoscope) to find out if one was better than the other.
The aim of this trial was to find out if one endoscope was better than the other at helping doctors to:
  • see the bowel more clearly and identify any suspicious areas
  • see polyps
  • remove polyps
  • do the colonoscopy more easily and so cause less discomfort

Summary of results

The trial team found that one camera called the HD-PHL was better at finding a certain type of polyp and adenoma.
Polyps Open a glossary item and adenomas Open a glossary item can be either an outgrowth from the bowel wall or flat against the bowel wall. A polyp is less likely to develop into cancer than an adenoma is. 
This trial was open for people to join between May 2012 and August 2013.
These results were submitted to a journal to be published in 2019. 
About this trial
Everyone had a colonoscopy as part of the national bowel screening programme. Two different cameras were used:
  • standard definition Olympus Lucera (SD-OL)
  • high definition Pentax Hi-Line (HD-PHL)
This was a randomised trial. The people who took part were put into 1 of 2 groups. Neither they or their doctor chose which group they were in. 
129 people had their colonoscopy using the SD-OL. 
133 people had their colonoscopy using the HD-PHL. 
147 people were diagnosed with at least 1 polyp. The total number of polyps diagnosed was 347:
  • 194 polyps by the HD-PHL
  • 153 polyps by the SD-OL

The team looked at in how many people polyps and adenomas each camera found. 
Of the 133 people who had a colonoscopy using the HD-PHL camera:
  • 74 people (55.6%) had at least 1 polyp
  • 58 people (43.6%) had adenomas
Of the 129 people who had a colonoscopy using the SD-OL camera:
  • 73 people (56.6%) had at least 1 polyp
  • 59 people (45.7%) had adenomas
The trial team said this shows that the performance of both cameras was very similar. 
Flat polyps and flat adenomas are more likely to develop into cancers. The researchers looked at how good each camera was at detecting these. They found that:
  • just under 19 out of every 100 times (18.6%) the HD-PHL detected flat polyps and flat adenomas
  • just over 5 out of every 100 times (5.2%) the SD-OL detected flat polyps and flat adenomas 

The trial team concluded the HD-PHL was better at detecting flat adenomas and polyps. This advantage could lead to a lower rate of colon cancer happening after a colonoscopy. And could improve the prevention and detection of colon cancer. 
Where this information comes from
We have based this summary on information from the research team.  As far as we are aware, the information they sent us has not been reviewed independently (peer reviewed Open a glossary item) or published in a medical journal yet. The figures we quote above were provided by the research team. We have not analysed the data ourselves.

Recruitment start:

Recruitment end:

How to join a clinical trial

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Chief Investigator

Dr Matthew Banks

Supported by

Experimental Cancer Medicine Centre (ECMC)
University College London (UCL)

If you have questions about the trial please contact our cancer information nurses

Freephone 0808 800 4040

Last review date

CRUK internal database number:


Please note - unless we state otherwise in the summary, you need to talk to your doctor about joining a trial.

Alan took part in a clinical trial for bowel cancer patients

A picture of ALan

“I think it’s essential that people keep signing up to these type of trials to push research forward.”

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