
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.
Please note - this trial is no longer recruiting patients. We hope to add results when they are available.
This trial is looking at a new drug APD515 to treat people with cancer who have a dry mouth.
Doctors know that a dry mouth is a common problem for people with advanced cancer.
A dry mouth can be treated with mouth washes and artificial saliva. But this treatment doesn’t always work very well.
Doctors want to find out if APD515 works better than existing treatment for people with a dry mouth.
The aim of this trial is to find out
You may be able to enter this trial if you
You cannot enter this trial if you
This is a randomised trial. The people taking part are put into 1 of 2 treatment groups. Neither you nor your doctor will be able to decide which group you are in. You will not know which group you are in as everyone has treatment that looks the same. This is called a ‘double blind’ trial.
APD515 is a liquid that you spread onto the lining of your mouth, and leave there without swallowing for 2 minutes. You then swallow any remaining liquid.
The people in group 1 have
The people in group 2 have
You fill out a questionnaire before you start treatment, and twice a week when you have treatment. The questionnaire will ask about any side effects you have had and about your dry mouth. This is called a quality of life study.
You see the doctors and have some tests before you start each week of treatment and on the last day of each treatment. The tests include
Researchers will ring you at home in the middle of each treatment week, to find out how you are.
Once you have finished your 2nd week of treatment there are no more hospital visits for the trial.
The most common side effects of APD515 are
Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.
Dr Andrew Davies
Acacia Pharma Ltd
National Institute for Health Research Cancer Research Network (NCRN)
Freephone 0808 800 4040
Around 1 in 5 people diagnosed with cancer in the UK take part in a clinical trial.